Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer

BACKGROUND: Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously. METHODS: Prospective cohort of 23 356 postmenopausal women with 471 Type I and 71 Type II EC cases. RESULTS: Type I EC was statistically significantly ass...

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Autores principales: Uccella, S, Mariani, A, Wang, A H, Vierkant, R A, Cliby, W A, Robien, K, Anderson, K E, Cerhan, J R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790186/
https://www.ncbi.nlm.nih.gov/pubmed/24022184
http://dx.doi.org/10.1038/bjc.2013.540
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author Uccella, S
Mariani, A
Wang, A H
Vierkant, R A
Cliby, W A
Robien, K
Anderson, K E
Cerhan, J R
author_facet Uccella, S
Mariani, A
Wang, A H
Vierkant, R A
Cliby, W A
Robien, K
Anderson, K E
Cerhan, J R
author_sort Uccella, S
collection PubMed
description BACKGROUND: Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously. METHODS: Prospective cohort of 23 356 postmenopausal women with 471 Type I and 71 Type II EC cases. RESULTS: Type I EC was statistically significantly associated with caffeinated (relative risk (RR)=0.65 for 4+ cups per day vs ⩽1 cup per month: 95% confidence interval (CI): 0.47–0.89) but not decaffeinated (RR=0.76; 95% CI: 0.50–1.15) coffee intake; there were no associations with tea, cola or chocolate, or for Type II EC. The inverse association with caffeinated coffee intake was specific to women with a body mass index 30+ kg m(−2) (RR=0.56; 95% CI: 0.36–0.89). CONCLUSION: Coffee may protect against Type I EC in obese postmenopausal women.
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spelling pubmed-37901862014-10-01 Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer Uccella, S Mariani, A Wang, A H Vierkant, R A Cliby, W A Robien, K Anderson, K E Cerhan, J R Br J Cancer Short Communication BACKGROUND: Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously. METHODS: Prospective cohort of 23 356 postmenopausal women with 471 Type I and 71 Type II EC cases. RESULTS: Type I EC was statistically significantly associated with caffeinated (relative risk (RR)=0.65 for 4+ cups per day vs ⩽1 cup per month: 95% confidence interval (CI): 0.47–0.89) but not decaffeinated (RR=0.76; 95% CI: 0.50–1.15) coffee intake; there were no associations with tea, cola or chocolate, or for Type II EC. The inverse association with caffeinated coffee intake was specific to women with a body mass index 30+ kg m(−2) (RR=0.56; 95% CI: 0.36–0.89). CONCLUSION: Coffee may protect against Type I EC in obese postmenopausal women. Nature Publishing Group 2013-10-01 2013-09-10 /pmc/articles/PMC3790186/ /pubmed/24022184 http://dx.doi.org/10.1038/bjc.2013.540 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Short Communication
Uccella, S
Mariani, A
Wang, A H
Vierkant, R A
Cliby, W A
Robien, K
Anderson, K E
Cerhan, J R
Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer
title Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer
title_full Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer
title_fullStr Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer
title_full_unstemmed Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer
title_short Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer
title_sort intake of coffee, caffeine and other methylxanthines and risk of type i vs type ii endometrial cancer
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790186/
https://www.ncbi.nlm.nih.gov/pubmed/24022184
http://dx.doi.org/10.1038/bjc.2013.540
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