Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging

Drug transit through the blood-brain barrier (BBB) is essential for therapeutic responses in malignant glioma. Conventional methods for assessment of BBB penetrance require synthesis of isotopically labeled drug derivatives. Here, we report a new methodology using matrix assisted laser desorption io...

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Detalles Bibliográficos
Autores principales: Liu, Xiaohui, Ide, Jennifer L., Norton, Isaiah, Marchionni, Mark A., Ebling, Maritza C., Wang, Lan Y., Davis, Erin, Sauvageot, Claire M., Kesari, Santosh, Kellersberger, Katherine A., Easterling, Michael L., Santagata, Sandro, Stuart, Darrin D., Alberta, John, Agar, Jeffrey N., Stiles, Charles D., Agar, Nathalie Y. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790202/
https://www.ncbi.nlm.nih.gov/pubmed/24091529
http://dx.doi.org/10.1038/srep02859

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