14a-Hy­droxy-12-methyl-10-(4-methyl­phen­yl)-8,9,9a,10,12,13,14,14a-octa­hydro-10a,14-methano-5H-indeno­[2′,1′:4,5]azepino[3,4-b]pyrrolizine-5,15(7H,11H)-dione

In the title compound, C(27)H(28)N(2)O(3), each of the pyrrolidine rings adopts a twisted conformation, as does the cyclo­pentane ring. The indane ring has an r.m.s deviation of 0.0693 Å. The dihedral angle between the mean plane of the pyrrolizine ring and indane system is 82.58 (1)°. The piperidin...

Descripción completa

Detalles Bibliográficos
Autores principales: Nagalakshmi, R. A., Suresh, J., Malathi, K., Kumar, R. Ranjith, Lakshman, P. L. Nilantha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2013
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790438/
https://www.ncbi.nlm.nih.gov/pubmed/24098257
http://dx.doi.org/10.1107/S1600536813025592
_version_ 1782286597503320064
author Nagalakshmi, R. A.
Suresh, J.
Malathi, K.
Kumar, R. Ranjith
Lakshman, P. L. Nilantha
author_facet Nagalakshmi, R. A.
Suresh, J.
Malathi, K.
Kumar, R. Ranjith
Lakshman, P. L. Nilantha
author_sort Nagalakshmi, R. A.
collection PubMed
description In the title compound, C(27)H(28)N(2)O(3), each of the pyrrolidine rings adopts a twisted conformation, as does the cyclo­pentane ring. The indane ring has an r.m.s deviation of 0.0693 Å. The dihedral angle between the mean plane of the pyrrolizine ring and indane system is 82.58 (1)°. The piperidine ring has the methyl substituent in an equatorial position and adopts a twisted chair conformation. The mol­ecular structure is stabilized by a weak intra­molecular O—H⋯N inter­action.
format Online
Article
Text
id pubmed-3790438
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher International Union of Crystallography
record_format MEDLINE/PubMed
spelling pubmed-37904382013-10-04 14a-Hy­droxy-12-methyl-10-(4-methyl­phen­yl)-8,9,9a,10,12,13,14,14a-octa­hydro-10a,14-methano-5H-indeno­[2′,1′:4,5]azepino[3,4-b]pyrrolizine-5,15(7H,11H)-dione Nagalakshmi, R. A. Suresh, J. Malathi, K. Kumar, R. Ranjith Lakshman, P. L. Nilantha Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(27)H(28)N(2)O(3), each of the pyrrolidine rings adopts a twisted conformation, as does the cyclo­pentane ring. The indane ring has an r.m.s deviation of 0.0693 Å. The dihedral angle between the mean plane of the pyrrolizine ring and indane system is 82.58 (1)°. The piperidine ring has the methyl substituent in an equatorial position and adopts a twisted chair conformation. The mol­ecular structure is stabilized by a weak intra­molecular O—H⋯N inter­action. International Union of Crystallography 2013-09-21 /pmc/articles/PMC3790438/ /pubmed/24098257 http://dx.doi.org/10.1107/S1600536813025592 Text en © Nagalakshmi et al. 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Nagalakshmi, R. A.
Suresh, J.
Malathi, K.
Kumar, R. Ranjith
Lakshman, P. L. Nilantha
14a-Hy­droxy-12-methyl-10-(4-methyl­phen­yl)-8,9,9a,10,12,13,14,14a-octa­hydro-10a,14-methano-5H-indeno­[2′,1′:4,5]azepino[3,4-b]pyrrolizine-5,15(7H,11H)-dione
title 14a-Hy­droxy-12-methyl-10-(4-methyl­phen­yl)-8,9,9a,10,12,13,14,14a-octa­hydro-10a,14-methano-5H-indeno­[2′,1′:4,5]azepino[3,4-b]pyrrolizine-5,15(7H,11H)-dione
title_full 14a-Hy­droxy-12-methyl-10-(4-methyl­phen­yl)-8,9,9a,10,12,13,14,14a-octa­hydro-10a,14-methano-5H-indeno­[2′,1′:4,5]azepino[3,4-b]pyrrolizine-5,15(7H,11H)-dione
title_fullStr 14a-Hy­droxy-12-methyl-10-(4-methyl­phen­yl)-8,9,9a,10,12,13,14,14a-octa­hydro-10a,14-methano-5H-indeno­[2′,1′:4,5]azepino[3,4-b]pyrrolizine-5,15(7H,11H)-dione
title_full_unstemmed 14a-Hy­droxy-12-methyl-10-(4-methyl­phen­yl)-8,9,9a,10,12,13,14,14a-octa­hydro-10a,14-methano-5H-indeno­[2′,1′:4,5]azepino[3,4-b]pyrrolizine-5,15(7H,11H)-dione
title_short 14a-Hy­droxy-12-methyl-10-(4-methyl­phen­yl)-8,9,9a,10,12,13,14,14a-octa­hydro-10a,14-methano-5H-indeno­[2′,1′:4,5]azepino[3,4-b]pyrrolizine-5,15(7H,11H)-dione
title_sort 14a-hy­droxy-12-methyl-10-(4-methyl­phen­yl)-8,9,9a,10,12,13,14,14a-octa­hydro-10a,14-methano-5h-indeno­[2′,1′:4,5]azepino[3,4-b]pyrrolizine-5,15(7h,11h)-dione
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790438/
https://www.ncbi.nlm.nih.gov/pubmed/24098257
http://dx.doi.org/10.1107/S1600536813025592
work_keys_str_mv AT nagalakshmira 14ahydroxy12methyl104methylphenyl899a1012131414aoctahydro10a14methano5hindeno2145azepino34bpyrrolizine5157h11hdione
AT sureshj 14ahydroxy12methyl104methylphenyl899a1012131414aoctahydro10a14methano5hindeno2145azepino34bpyrrolizine5157h11hdione
AT malathik 14ahydroxy12methyl104methylphenyl899a1012131414aoctahydro10a14methano5hindeno2145azepino34bpyrrolizine5157h11hdione
AT kumarrranjith 14ahydroxy12methyl104methylphenyl899a1012131414aoctahydro10a14methano5hindeno2145azepino34bpyrrolizine5157h11hdione
AT lakshmanplnilantha 14ahydroxy12methyl104methylphenyl899a1012131414aoctahydro10a14methano5hindeno2145azepino34bpyrrolizine5157h11hdione

Ejemplares similares