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B lymphocyte antigen receptor signaling: initiation, amplification, and regulation

B lymphocytes and their differentiated daughters are charged with responding to the myriad pathogens in our environment and production of protective antibodies. A sample of the protective antibody produced by each clone is utilized as a component of the cell’s antigen receptor (BCR). Transmembrane s...

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Detalles Bibliográficos
Autores principales: Packard, Thomas A., Cambier, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790562/
https://www.ncbi.nlm.nih.gov/pubmed/24167721
http://dx.doi.org/10.12703/P5-40
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author Packard, Thomas A.
Cambier, John C.
author_facet Packard, Thomas A.
Cambier, John C.
author_sort Packard, Thomas A.
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description B lymphocytes and their differentiated daughters are charged with responding to the myriad pathogens in our environment and production of protective antibodies. A sample of the protective antibody produced by each clone is utilized as a component of the cell’s antigen receptor (BCR). Transmembrane signals generated upon antigen binding to this receptor provide the primary directive for the cell’s subsequent response. In this report, we discuss recent progress and current controversy regarding B cell receptor signal initiation, transduction and regulation.
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spelling pubmed-37905622013-10-28 B lymphocyte antigen receptor signaling: initiation, amplification, and regulation Packard, Thomas A. Cambier, John C. F1000Prime Rep Review Article B lymphocytes and their differentiated daughters are charged with responding to the myriad pathogens in our environment and production of protective antibodies. A sample of the protective antibody produced by each clone is utilized as a component of the cell’s antigen receptor (BCR). Transmembrane signals generated upon antigen binding to this receptor provide the primary directive for the cell’s subsequent response. In this report, we discuss recent progress and current controversy regarding B cell receptor signal initiation, transduction and regulation. Faculty of 1000 Ltd 2013-10-01 /pmc/articles/PMC3790562/ /pubmed/24167721 http://dx.doi.org/10.12703/P5-40 Text en © 2013 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Packard, Thomas A.
Cambier, John C.
B lymphocyte antigen receptor signaling: initiation, amplification, and regulation
title B lymphocyte antigen receptor signaling: initiation, amplification, and regulation
title_full B lymphocyte antigen receptor signaling: initiation, amplification, and regulation
title_fullStr B lymphocyte antigen receptor signaling: initiation, amplification, and regulation
title_full_unstemmed B lymphocyte antigen receptor signaling: initiation, amplification, and regulation
title_short B lymphocyte antigen receptor signaling: initiation, amplification, and regulation
title_sort b lymphocyte antigen receptor signaling: initiation, amplification, and regulation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790562/
https://www.ncbi.nlm.nih.gov/pubmed/24167721
http://dx.doi.org/10.12703/P5-40
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