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B lymphocyte antigen receptor signaling: initiation, amplification, and regulation
B lymphocytes and their differentiated daughters are charged with responding to the myriad pathogens in our environment and production of protective antibodies. A sample of the protective antibody produced by each clone is utilized as a component of the cell’s antigen receptor (BCR). Transmembrane s...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculty of 1000 Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790562/ https://www.ncbi.nlm.nih.gov/pubmed/24167721 http://dx.doi.org/10.12703/P5-40 |
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author | Packard, Thomas A. Cambier, John C. |
author_facet | Packard, Thomas A. Cambier, John C. |
author_sort | Packard, Thomas A. |
collection | PubMed |
description | B lymphocytes and their differentiated daughters are charged with responding to the myriad pathogens in our environment and production of protective antibodies. A sample of the protective antibody produced by each clone is utilized as a component of the cell’s antigen receptor (BCR). Transmembrane signals generated upon antigen binding to this receptor provide the primary directive for the cell’s subsequent response. In this report, we discuss recent progress and current controversy regarding B cell receptor signal initiation, transduction and regulation. |
format | Online Article Text |
id | pubmed-3790562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Faculty of 1000 Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37905622013-10-28 B lymphocyte antigen receptor signaling: initiation, amplification, and regulation Packard, Thomas A. Cambier, John C. F1000Prime Rep Review Article B lymphocytes and their differentiated daughters are charged with responding to the myriad pathogens in our environment and production of protective antibodies. A sample of the protective antibody produced by each clone is utilized as a component of the cell’s antigen receptor (BCR). Transmembrane signals generated upon antigen binding to this receptor provide the primary directive for the cell’s subsequent response. In this report, we discuss recent progress and current controversy regarding B cell receptor signal initiation, transduction and regulation. Faculty of 1000 Ltd 2013-10-01 /pmc/articles/PMC3790562/ /pubmed/24167721 http://dx.doi.org/10.12703/P5-40 Text en © 2013 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes |
spellingShingle | Review Article Packard, Thomas A. Cambier, John C. B lymphocyte antigen receptor signaling: initiation, amplification, and regulation |
title | B lymphocyte antigen receptor signaling: initiation, amplification, and regulation |
title_full | B lymphocyte antigen receptor signaling: initiation, amplification, and regulation |
title_fullStr | B lymphocyte antigen receptor signaling: initiation, amplification, and regulation |
title_full_unstemmed | B lymphocyte antigen receptor signaling: initiation, amplification, and regulation |
title_short | B lymphocyte antigen receptor signaling: initiation, amplification, and regulation |
title_sort | b lymphocyte antigen receptor signaling: initiation, amplification, and regulation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790562/ https://www.ncbi.nlm.nih.gov/pubmed/24167721 http://dx.doi.org/10.12703/P5-40 |
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