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Research advances in esophageal diseases: bench to bedside
Over the last year, significant steps have been made toward understanding the pathogenesis of esophageal diseases and translating this knowledge to clinical practice. Gastroesophageal reflux disease (GERD) is the most common outpatient diagnosis in gastroenterology and has a high prevalence in the g...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculty of 1000 Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790564/ https://www.ncbi.nlm.nih.gov/pubmed/24167725 http://dx.doi.org/10.12703/P5-44 |
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author | di Pietro, Massimiliano Fitzgerald, Rebecca C |
author_facet | di Pietro, Massimiliano Fitzgerald, Rebecca C |
author_sort | di Pietro, Massimiliano |
collection | PubMed |
description | Over the last year, significant steps have been made toward understanding the pathogenesis of esophageal diseases and translating this knowledge to clinical practice. Gastroesophageal reflux disease (GERD) is the most common outpatient diagnosis in gastroenterology and has a high prevalence in the general population. As many as 40% of patients with GERD have incomplete response to medical therapy, and the pathophysiological mechanisms underlying lack of response are now better understood. Novel medical and minimally invasive interventions are available to optimize management of GERD. Esophageal cancer, regardless of the histological subtype, has among the worst survival statistics among all malignancies. Taking advantage of technological advances in genome sequencing, the mutational spectra in esophageal cancer are now emerging, offering novel avenues for targeted therapies. Early diagnosis is another strand for improving survival. While genome-wide association studies are providing insights into genetic susceptibility, novel approaches to early detection of cancer are being devised through the use of biomarkers applied to esophageal samples and as part of imaging technologies. Dysmotility and eosinophilic esophagitis are the differential diagnoses in patients with dysphagia. New pathophysiological classifications have improved the management of motility disorders. Meanwhile, exciting progress has been made in the endoscopic management of these conditions. Eosinophilic esophagitis is still a relatively new entity, and the pathogenesis remains poorly understood. However, it is now clear that an allergic reaction to food plays an important role, and dietary interventions as well as biologic agents to block the inflammatory cascade are novel, promising fields of clinical research. |
format | Online Article Text |
id | pubmed-3790564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Faculty of 1000 Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37905642013-10-28 Research advances in esophageal diseases: bench to bedside di Pietro, Massimiliano Fitzgerald, Rebecca C F1000Prime Rep Review Article Over the last year, significant steps have been made toward understanding the pathogenesis of esophageal diseases and translating this knowledge to clinical practice. Gastroesophageal reflux disease (GERD) is the most common outpatient diagnosis in gastroenterology and has a high prevalence in the general population. As many as 40% of patients with GERD have incomplete response to medical therapy, and the pathophysiological mechanisms underlying lack of response are now better understood. Novel medical and minimally invasive interventions are available to optimize management of GERD. Esophageal cancer, regardless of the histological subtype, has among the worst survival statistics among all malignancies. Taking advantage of technological advances in genome sequencing, the mutational spectra in esophageal cancer are now emerging, offering novel avenues for targeted therapies. Early diagnosis is another strand for improving survival. While genome-wide association studies are providing insights into genetic susceptibility, novel approaches to early detection of cancer are being devised through the use of biomarkers applied to esophageal samples and as part of imaging technologies. Dysmotility and eosinophilic esophagitis are the differential diagnoses in patients with dysphagia. New pathophysiological classifications have improved the management of motility disorders. Meanwhile, exciting progress has been made in the endoscopic management of these conditions. Eosinophilic esophagitis is still a relatively new entity, and the pathogenesis remains poorly understood. However, it is now clear that an allergic reaction to food plays an important role, and dietary interventions as well as biologic agents to block the inflammatory cascade are novel, promising fields of clinical research. Faculty of 1000 Ltd 2013-10-01 /pmc/articles/PMC3790564/ /pubmed/24167725 http://dx.doi.org/10.12703/P5-44 Text en © 2013 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes |
spellingShingle | Review Article di Pietro, Massimiliano Fitzgerald, Rebecca C Research advances in esophageal diseases: bench to bedside |
title | Research advances in esophageal diseases: bench to bedside |
title_full | Research advances in esophageal diseases: bench to bedside |
title_fullStr | Research advances in esophageal diseases: bench to bedside |
title_full_unstemmed | Research advances in esophageal diseases: bench to bedside |
title_short | Research advances in esophageal diseases: bench to bedside |
title_sort | research advances in esophageal diseases: bench to bedside |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790564/ https://www.ncbi.nlm.nih.gov/pubmed/24167725 http://dx.doi.org/10.12703/P5-44 |
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