MEK Inhibitor U0126 Reverses Protection of Axons from Wallerian Degeneration Independently of MEK–ERK Signaling

Wallerian degeneration is delayed when sufficient levels of proteins with NMNAT activity are maintained within axons after injury. This has been proposed to form the basis of 'slow Wallerian degeneration' (Wld (S)), a neuroprotective phenotype conferred by an aberrant fusion protein, Wld(S...

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Detalles Bibliográficos
Autores principales: Evans, Catherine, Cook, Simon J., Coleman, Michael P., Gilley, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790678/
https://www.ncbi.nlm.nih.gov/pubmed/24124570
http://dx.doi.org/10.1371/journal.pone.0076505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790678/
https://www.ncbi.nlm.nih.gov/pubmed/24124570
http://dx.doi.org/10.1371/journal.pone.0076505

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