Dissection of the Beta-Globin Replication-Initiation Region Reveals Specific Requirements for Replicator Elements during Gene Amplification

Gene amplification plays a pivotal role in malignant transformation of human cells. A plasmid with both a mammalian replication-initiation region (IR)/origin/replicator and a nuclear matrix-attachment region (MAR) is spontaneously amplified in transfected cells by a mechanism that involves amplifica...

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Detalles Bibliográficos
Autores principales: Okada, Naoya, Shimizu, Noriaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790722/
https://www.ncbi.nlm.nih.gov/pubmed/24124615
http://dx.doi.org/10.1371/journal.pone.0077350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790722/
https://www.ncbi.nlm.nih.gov/pubmed/24124615
http://dx.doi.org/10.1371/journal.pone.0077350

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