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Non-Immunogenicity of Overlapping Gag Peptides Pulsed on Autologous Cells after Vaccination of HIV Infected Individuals

BACKGROUND: HIV Gag-specific CD4+ and CD8+ T-cell responses are important for HIV immune control. Pulsing overlapping Gag peptides on autologous lymphocytes (OPAL) has proven immunogenic and effective in reducing viral loads in multiple pigtail macaque studies, warranting clinical evaluation. METHOD...

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Detalles Bibliográficos
Autores principales:	Kløverpris, Henrik N., Jackson, Akil, Handley, Amanda, Hayes, Peter, Gilmour, Jill, Riddell, Lynn, Chen, Fabian, Atkins, Mark, Boffito, Marta, Walker, Bruce D., Ackland, Jim, Sullivan, Mark, Goulder, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790804/ https://www.ncbi.nlm.nih.gov/pubmed/24124451 http://dx.doi.org/10.1371/journal.pone.0074389

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