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Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks

We report the experimental verification of noise-enhanced logic behaviour in an electronic analog of a synthetic genetic network, composed of two repressors and two constitutive promoters. We observe good agreement between circuit measurements and numerical prediction, with the circuit allowing for...

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Autores principales: Hellen, Edward H., Dana, Syamal K., Kurths, Jürgen, Kehler, Elizabeth, Sinha, Sudeshna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790844/
https://www.ncbi.nlm.nih.gov/pubmed/24124531
http://dx.doi.org/10.1371/journal.pone.0076032
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author Hellen, Edward H.
Dana, Syamal K.
Kurths, Jürgen
Kehler, Elizabeth
Sinha, Sudeshna
author_facet Hellen, Edward H.
Dana, Syamal K.
Kurths, Jürgen
Kehler, Elizabeth
Sinha, Sudeshna
author_sort Hellen, Edward H.
collection PubMed
description We report the experimental verification of noise-enhanced logic behaviour in an electronic analog of a synthetic genetic network, composed of two repressors and two constitutive promoters. We observe good agreement between circuit measurements and numerical prediction, with the circuit allowing for robust logic operations in an optimal window of noise. Namely, the input-output characteristics of a logic gate is reproduced faithfully under moderate noise, which is a manifestation of the phenomenon known as Logical Stochastic Resonance. The two dynamical variables in the system yield complementary logic behaviour simultaneously. The system is easily morphed from AND/NAND to OR/NOR logic.
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spelling pubmed-37908442013-10-11 Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks Hellen, Edward H. Dana, Syamal K. Kurths, Jürgen Kehler, Elizabeth Sinha, Sudeshna PLoS One Research Article We report the experimental verification of noise-enhanced logic behaviour in an electronic analog of a synthetic genetic network, composed of two repressors and two constitutive promoters. We observe good agreement between circuit measurements and numerical prediction, with the circuit allowing for robust logic operations in an optimal window of noise. Namely, the input-output characteristics of a logic gate is reproduced faithfully under moderate noise, which is a manifestation of the phenomenon known as Logical Stochastic Resonance. The two dynamical variables in the system yield complementary logic behaviour simultaneously. The system is easily morphed from AND/NAND to OR/NOR logic. Public Library of Science 2013-10-04 /pmc/articles/PMC3790844/ /pubmed/24124531 http://dx.doi.org/10.1371/journal.pone.0076032 Text en © 2013 Hellen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hellen, Edward H.
Dana, Syamal K.
Kurths, Jürgen
Kehler, Elizabeth
Sinha, Sudeshna
Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks
title Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks
title_full Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks
title_fullStr Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks
title_full_unstemmed Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks
title_short Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks
title_sort noise-aided logic in an electronic analog of synthetic genetic networks
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790844/
https://www.ncbi.nlm.nih.gov/pubmed/24124531
http://dx.doi.org/10.1371/journal.pone.0076032
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