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Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks
We report the experimental verification of noise-enhanced logic behaviour in an electronic analog of a synthetic genetic network, composed of two repressors and two constitutive promoters. We observe good agreement between circuit measurements and numerical prediction, with the circuit allowing for...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790844/ https://www.ncbi.nlm.nih.gov/pubmed/24124531 http://dx.doi.org/10.1371/journal.pone.0076032 |
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author | Hellen, Edward H. Dana, Syamal K. Kurths, Jürgen Kehler, Elizabeth Sinha, Sudeshna |
author_facet | Hellen, Edward H. Dana, Syamal K. Kurths, Jürgen Kehler, Elizabeth Sinha, Sudeshna |
author_sort | Hellen, Edward H. |
collection | PubMed |
description | We report the experimental verification of noise-enhanced logic behaviour in an electronic analog of a synthetic genetic network, composed of two repressors and two constitutive promoters. We observe good agreement between circuit measurements and numerical prediction, with the circuit allowing for robust logic operations in an optimal window of noise. Namely, the input-output characteristics of a logic gate is reproduced faithfully under moderate noise, which is a manifestation of the phenomenon known as Logical Stochastic Resonance. The two dynamical variables in the system yield complementary logic behaviour simultaneously. The system is easily morphed from AND/NAND to OR/NOR logic. |
format | Online Article Text |
id | pubmed-3790844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37908442013-10-11 Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks Hellen, Edward H. Dana, Syamal K. Kurths, Jürgen Kehler, Elizabeth Sinha, Sudeshna PLoS One Research Article We report the experimental verification of noise-enhanced logic behaviour in an electronic analog of a synthetic genetic network, composed of two repressors and two constitutive promoters. We observe good agreement between circuit measurements and numerical prediction, with the circuit allowing for robust logic operations in an optimal window of noise. Namely, the input-output characteristics of a logic gate is reproduced faithfully under moderate noise, which is a manifestation of the phenomenon known as Logical Stochastic Resonance. The two dynamical variables in the system yield complementary logic behaviour simultaneously. The system is easily morphed from AND/NAND to OR/NOR logic. Public Library of Science 2013-10-04 /pmc/articles/PMC3790844/ /pubmed/24124531 http://dx.doi.org/10.1371/journal.pone.0076032 Text en © 2013 Hellen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Hellen, Edward H. Dana, Syamal K. Kurths, Jürgen Kehler, Elizabeth Sinha, Sudeshna Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks |
title | Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks |
title_full | Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks |
title_fullStr | Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks |
title_full_unstemmed | Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks |
title_short | Noise-Aided Logic in an Electronic Analog of Synthetic Genetic Networks |
title_sort | noise-aided logic in an electronic analog of synthetic genetic networks |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790844/ https://www.ncbi.nlm.nih.gov/pubmed/24124531 http://dx.doi.org/10.1371/journal.pone.0076032 |
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