Identification of Leptospira interrogans Phospholipase C as a Novel Virulence Factor Responsible for Intracellular Free Calcium Ion Elevation during Macrophage Death

BACKGROUND: Leptospira-induced macrophage death has been confirmed to play a crucial role in pathogenesis of leptospirosis, a worldwide zoonotic infectious disease. Intracellular free Ca(2+) concentration ([Ca(2+)]i) elevation induced by infection can cause cell death, but [Ca(2+)]i changes and high...

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Detalles Bibliográficos
Autores principales: Zhao, Jing-Fang, Chen, Hong-Hu, Ojcius, David M., Zhao, Xin, Sun, Dexter, Ge, Yu-Mei, Zheng, Lin-Li, Lin, Xu’ai, Li, Lan-Juan, Yan, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790881/
https://www.ncbi.nlm.nih.gov/pubmed/24124502
http://dx.doi.org/10.1371/journal.pone.0075652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790881/
https://www.ncbi.nlm.nih.gov/pubmed/24124502
http://dx.doi.org/10.1371/journal.pone.0075652

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