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Understanding pathogenic single-nucleotide polymorphisms in multidomain proteins – studies of isolated domains are not enough
Studying the effects of pathogenic mutations is more complex in multidomain proteins when compared with single domains: mutations occurring at domain boundaries may have a large effect on a neighbouring domain that will not be detected in a single-domain system. To demonstrate this, we present a stu...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790955/ https://www.ncbi.nlm.nih.gov/pubmed/23241237 http://dx.doi.org/10.1111/febs.12094 |