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Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers

The effects of a β-dunnione compound MB12662 on the gastric secretion and ulcers were investigated in rats. In order to assess the effects of MB12662 on the gastric secretion and acidity, rats were subjected to pylorus ligation operation, and 6 hours later, gastric fluid was collected. Treatment wit...

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Autores principales: Jo, In-Geun, Park, Dongsun, Kyung, Jangbeen, Kim, Dajeong, Cai, Jingmei, Kim, Jihyun, Kwak, Tae Hwan, Yoo, Sang-Ku, Jeong, Heon-Sang, Kim, Yun-Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791353/
https://www.ncbi.nlm.nih.gov/pubmed/24106514
http://dx.doi.org/10.5625/lar.2013.29.3.178
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author Jo, In-Geun
Park, Dongsun
Kyung, Jangbeen
Kim, Dajeong
Cai, Jingmei
Kim, Jihyun
Kwak, Tae Hwan
Yoo, Sang-Ku
Jeong, Heon-Sang
Kim, Yun-Bae
author_facet Jo, In-Geun
Park, Dongsun
Kyung, Jangbeen
Kim, Dajeong
Cai, Jingmei
Kim, Jihyun
Kwak, Tae Hwan
Yoo, Sang-Ku
Jeong, Heon-Sang
Kim, Yun-Bae
author_sort Jo, In-Geun
collection PubMed
description The effects of a β-dunnione compound MB12662 on the gastric secretion and ulcers were investigated in rats. In order to assess the effects of MB12662 on the gastric secretion and acidity, rats were subjected to pylorus ligation operation, and 6 hours later, gastric fluid was collected. Treatment with MB12662 reduced the gastric fluid volume to 47.3% of control level and increased pH. In an alcohol-induced ulcer model, rats were orally administered 3 mL/kg of ethanol, and 1 hour later, the ulcer lesions ware measured under a stereomicroscope. MB12662 reduced ulcer index in a dose-dependent manner which was much stronger than a proton-pump inhibitor pantoprazole. In a stress-induced ulcer model, rats were subjected to water-immersion restraint stress, and 5 hours later, the ulcer lesions ware examined. MB12662 also attenuated the stress-induced gastric lesions, although the efficacy of MB12662 was lower than that of pantoprazole. Therefore, it is suggested that MB12662 could be a candidate compound for the prevention or treatment of gastric ulcers induced by gastric over-secretion and alcoholic hangover.
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spelling pubmed-37913532013-10-08 Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers Jo, In-Geun Park, Dongsun Kyung, Jangbeen Kim, Dajeong Cai, Jingmei Kim, Jihyun Kwak, Tae Hwan Yoo, Sang-Ku Jeong, Heon-Sang Kim, Yun-Bae Lab Anim Res Letter The effects of a β-dunnione compound MB12662 on the gastric secretion and ulcers were investigated in rats. In order to assess the effects of MB12662 on the gastric secretion and acidity, rats were subjected to pylorus ligation operation, and 6 hours later, gastric fluid was collected. Treatment with MB12662 reduced the gastric fluid volume to 47.3% of control level and increased pH. In an alcohol-induced ulcer model, rats were orally administered 3 mL/kg of ethanol, and 1 hour later, the ulcer lesions ware measured under a stereomicroscope. MB12662 reduced ulcer index in a dose-dependent manner which was much stronger than a proton-pump inhibitor pantoprazole. In a stress-induced ulcer model, rats were subjected to water-immersion restraint stress, and 5 hours later, the ulcer lesions ware examined. MB12662 also attenuated the stress-induced gastric lesions, although the efficacy of MB12662 was lower than that of pantoprazole. Therefore, it is suggested that MB12662 could be a candidate compound for the prevention or treatment of gastric ulcers induced by gastric over-secretion and alcoholic hangover. Korean Association for Laboratory Animal Science 2013-09 2013-09-27 /pmc/articles/PMC3791353/ /pubmed/24106514 http://dx.doi.org/10.5625/lar.2013.29.3.178 Text en Copyright © 2013 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter
Jo, In-Geun
Park, Dongsun
Kyung, Jangbeen
Kim, Dajeong
Cai, Jingmei
Kim, Jihyun
Kwak, Tae Hwan
Yoo, Sang-Ku
Jeong, Heon-Sang
Kim, Yun-Bae
Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers
title Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers
title_full Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers
title_fullStr Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers
title_full_unstemmed Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers
title_short Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers
title_sort inhibitory effects of a β-dunnione compound mb12662 on gastric secretion and ulcers
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791353/
https://www.ncbi.nlm.nih.gov/pubmed/24106514
http://dx.doi.org/10.5625/lar.2013.29.3.178
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