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Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers
The effects of a β-dunnione compound MB12662 on the gastric secretion and ulcers were investigated in rats. In order to assess the effects of MB12662 on the gastric secretion and acidity, rats were subjected to pylorus ligation operation, and 6 hours later, gastric fluid was collected. Treatment wit...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Association for Laboratory Animal Science
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791353/ https://www.ncbi.nlm.nih.gov/pubmed/24106514 http://dx.doi.org/10.5625/lar.2013.29.3.178 |
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author | Jo, In-Geun Park, Dongsun Kyung, Jangbeen Kim, Dajeong Cai, Jingmei Kim, Jihyun Kwak, Tae Hwan Yoo, Sang-Ku Jeong, Heon-Sang Kim, Yun-Bae |
author_facet | Jo, In-Geun Park, Dongsun Kyung, Jangbeen Kim, Dajeong Cai, Jingmei Kim, Jihyun Kwak, Tae Hwan Yoo, Sang-Ku Jeong, Heon-Sang Kim, Yun-Bae |
author_sort | Jo, In-Geun |
collection | PubMed |
description | The effects of a β-dunnione compound MB12662 on the gastric secretion and ulcers were investigated in rats. In order to assess the effects of MB12662 on the gastric secretion and acidity, rats were subjected to pylorus ligation operation, and 6 hours later, gastric fluid was collected. Treatment with MB12662 reduced the gastric fluid volume to 47.3% of control level and increased pH. In an alcohol-induced ulcer model, rats were orally administered 3 mL/kg of ethanol, and 1 hour later, the ulcer lesions ware measured under a stereomicroscope. MB12662 reduced ulcer index in a dose-dependent manner which was much stronger than a proton-pump inhibitor pantoprazole. In a stress-induced ulcer model, rats were subjected to water-immersion restraint stress, and 5 hours later, the ulcer lesions ware examined. MB12662 also attenuated the stress-induced gastric lesions, although the efficacy of MB12662 was lower than that of pantoprazole. Therefore, it is suggested that MB12662 could be a candidate compound for the prevention or treatment of gastric ulcers induced by gastric over-secretion and alcoholic hangover. |
format | Online Article Text |
id | pubmed-3791353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Korean Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37913532013-10-08 Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers Jo, In-Geun Park, Dongsun Kyung, Jangbeen Kim, Dajeong Cai, Jingmei Kim, Jihyun Kwak, Tae Hwan Yoo, Sang-Ku Jeong, Heon-Sang Kim, Yun-Bae Lab Anim Res Letter The effects of a β-dunnione compound MB12662 on the gastric secretion and ulcers were investigated in rats. In order to assess the effects of MB12662 on the gastric secretion and acidity, rats were subjected to pylorus ligation operation, and 6 hours later, gastric fluid was collected. Treatment with MB12662 reduced the gastric fluid volume to 47.3% of control level and increased pH. In an alcohol-induced ulcer model, rats were orally administered 3 mL/kg of ethanol, and 1 hour later, the ulcer lesions ware measured under a stereomicroscope. MB12662 reduced ulcer index in a dose-dependent manner which was much stronger than a proton-pump inhibitor pantoprazole. In a stress-induced ulcer model, rats were subjected to water-immersion restraint stress, and 5 hours later, the ulcer lesions ware examined. MB12662 also attenuated the stress-induced gastric lesions, although the efficacy of MB12662 was lower than that of pantoprazole. Therefore, it is suggested that MB12662 could be a candidate compound for the prevention or treatment of gastric ulcers induced by gastric over-secretion and alcoholic hangover. Korean Association for Laboratory Animal Science 2013-09 2013-09-27 /pmc/articles/PMC3791353/ /pubmed/24106514 http://dx.doi.org/10.5625/lar.2013.29.3.178 Text en Copyright © 2013 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Letter Jo, In-Geun Park, Dongsun Kyung, Jangbeen Kim, Dajeong Cai, Jingmei Kim, Jihyun Kwak, Tae Hwan Yoo, Sang-Ku Jeong, Heon-Sang Kim, Yun-Bae Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers |
title | Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers |
title_full | Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers |
title_fullStr | Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers |
title_full_unstemmed | Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers |
title_short | Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers |
title_sort | inhibitory effects of a β-dunnione compound mb12662 on gastric secretion and ulcers |
topic | Letter |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791353/ https://www.ncbi.nlm.nih.gov/pubmed/24106514 http://dx.doi.org/10.5625/lar.2013.29.3.178 |
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