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AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

While allosteric activation of AMPK is triggered only by AMP, binding of both ADP and AMP has been reported to promote phosphorylation and inhibit dephosphorylation at Thr172. Because cellular concentrations of ADP and ATP are higher than AMP, it has been proposed that ADP is the physiological signa...

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Detalles Bibliográficos
Autores principales:	Gowans, Graeme J., Hawley, Simon A., Ross, Fiona A., Hardie, D. Grahame
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791399/ https://www.ncbi.nlm.nih.gov/pubmed/24093679 http://dx.doi.org/10.1016/j.cmet.2013.08.019

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