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A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

In eukaryotes, DNA replication requires the origin recognition complex (ORC), a six-subunit assembly that promotes replisome formation on chromosomal origins. Despite extant homology between certain subunits, the degree of structural and organizational overlap between budding yeast and metazoan ORC...

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Detalles Bibliográficos
Autores principales:	Bleichert, Franziska, Balasov, Maxim, Chesnokov, Igor, Nogales, Eva, Botchan, Michael R, Berger, James M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2013
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791464/ https://www.ncbi.nlm.nih.gov/pubmed/24137536 http://dx.doi.org/10.7554/eLife.00882

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