OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3

SMAD transcription factors are key intracellular transducers of TGFβ cytokines. SMADs are tightly regulated to ensure balanced cellular responses to TGFβ signals. Ubiquitylation has a key role in regulating SMAD stability and activity. Several E3 ubiquitin ligases that regulate the turnover of SMADs...

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Detalles Bibliográficos
Autores principales: Herhaus, Lina, Al-Salihi, Mazin, Macartney, Thomas, Weidlich, Simone, Sapkota, Gopal P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791481/
https://www.ncbi.nlm.nih.gov/pubmed/24071738
http://dx.doi.org/10.1038/ncomms3519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791481/
https://www.ncbi.nlm.nih.gov/pubmed/24071738
http://dx.doi.org/10.1038/ncomms3519

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