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Age-Related Changes in Trabecular Meshwork Imaging
Purpose. To evaluate the normal aging effects on trabecular meshwork (TM) parameters using Fourier domain anterior segment optical coherence tomography (ASOCT) images. Patients and Methods. One eye from 45 participants with open angles was imaged. Two independent readers measured TM area, TM length,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791583/ https://www.ncbi.nlm.nih.gov/pubmed/24163814 http://dx.doi.org/10.1155/2013/295204 |
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author | Gold, Mark E. Kansara, Seema Nagi, Kundandeep S. Bell, Nicholas P. Blieden, Lauren S. Chuang, Alice Z. Baker, Laura A. Mankiewicz, Kimberly A. Feldman, Robert M. |
author_facet | Gold, Mark E. Kansara, Seema Nagi, Kundandeep S. Bell, Nicholas P. Blieden, Lauren S. Chuang, Alice Z. Baker, Laura A. Mankiewicz, Kimberly A. Feldman, Robert M. |
author_sort | Gold, Mark E. |
collection | PubMed |
description | Purpose. To evaluate the normal aging effects on trabecular meshwork (TM) parameters using Fourier domain anterior segment optical coherence tomography (ASOCT) images. Patients and Methods. One eye from 45 participants with open angles was imaged. Two independent readers measured TM area, TM length, and area and length of the TM interface shadow from 3 age groups (18–40, 41–60, and 61–80). Measurements were compared using stepwise regression analysis. Results. The average TM parameters were 0.0487 (±0.0092) mm(2) for TM area, 0.5502 (±0.1033) mm for TM length, 0.1623 (±0.341) mm(2) for TM interface shadow area, and 0.7755 (±0.1574) mm for TM interface shadow length. Interobserver reproducibility coefficients ranged from 0.45 (TM length) to 0.82 (TM area). TM area and length were not correlated with age. While the TM interface shadow length did not correlate with age, the TM interface shadow area increased with age. Race, sex, intraocular pressure, and gonioscopy score were not correlated with any TM parameters. Conclusion. Although the TM measurements were not correlated with age, the TM interface shadow area increased with age. Further study is required to determine whether there is any relationship between the age-related ASOCT findings of the TM interface shadow area and physiologic function. |
format | Online Article Text |
id | pubmed-3791583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37915832013-10-27 Age-Related Changes in Trabecular Meshwork Imaging Gold, Mark E. Kansara, Seema Nagi, Kundandeep S. Bell, Nicholas P. Blieden, Lauren S. Chuang, Alice Z. Baker, Laura A. Mankiewicz, Kimberly A. Feldman, Robert M. Biomed Res Int Clinical Study Purpose. To evaluate the normal aging effects on trabecular meshwork (TM) parameters using Fourier domain anterior segment optical coherence tomography (ASOCT) images. Patients and Methods. One eye from 45 participants with open angles was imaged. Two independent readers measured TM area, TM length, and area and length of the TM interface shadow from 3 age groups (18–40, 41–60, and 61–80). Measurements were compared using stepwise regression analysis. Results. The average TM parameters were 0.0487 (±0.0092) mm(2) for TM area, 0.5502 (±0.1033) mm for TM length, 0.1623 (±0.341) mm(2) for TM interface shadow area, and 0.7755 (±0.1574) mm for TM interface shadow length. Interobserver reproducibility coefficients ranged from 0.45 (TM length) to 0.82 (TM area). TM area and length were not correlated with age. While the TM interface shadow length did not correlate with age, the TM interface shadow area increased with age. Race, sex, intraocular pressure, and gonioscopy score were not correlated with any TM parameters. Conclusion. Although the TM measurements were not correlated with age, the TM interface shadow area increased with age. Further study is required to determine whether there is any relationship between the age-related ASOCT findings of the TM interface shadow area and physiologic function. Hindawi Publishing Corporation 2013 2013-09-19 /pmc/articles/PMC3791583/ /pubmed/24163814 http://dx.doi.org/10.1155/2013/295204 Text en Copyright © 2013 Mark E. Gold et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Gold, Mark E. Kansara, Seema Nagi, Kundandeep S. Bell, Nicholas P. Blieden, Lauren S. Chuang, Alice Z. Baker, Laura A. Mankiewicz, Kimberly A. Feldman, Robert M. Age-Related Changes in Trabecular Meshwork Imaging |
title | Age-Related Changes in Trabecular Meshwork Imaging |
title_full | Age-Related Changes in Trabecular Meshwork Imaging |
title_fullStr | Age-Related Changes in Trabecular Meshwork Imaging |
title_full_unstemmed | Age-Related Changes in Trabecular Meshwork Imaging |
title_short | Age-Related Changes in Trabecular Meshwork Imaging |
title_sort | age-related changes in trabecular meshwork imaging |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791583/ https://www.ncbi.nlm.nih.gov/pubmed/24163814 http://dx.doi.org/10.1155/2013/295204 |
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