Cdc48: A Swiss Army Knife of Cell Biology

Cdc48 (also called VCP and p97) is an abundant protein that plays essential regulatory functions in a broad array of cellular processes. Working with various cofactors, Cdc48 utilizes its ATPase activity to promote the assembly and disassembly of protein complexes. Here, we review key biological fun...

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Detalles Bibliográficos
Autores principales: Baek, Guem Hee, Cheng, Haili, Choe, Vitnary, Bao, Xin, Shao, Jia, Luo, Shiwen, Rao, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791797/
https://www.ncbi.nlm.nih.gov/pubmed/24167726
http://dx.doi.org/10.1155/2013/183421
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author Baek, Guem Hee
Cheng, Haili
Choe, Vitnary
Bao, Xin
Shao, Jia
Luo, Shiwen
Rao, Hai
author_facet Baek, Guem Hee
Cheng, Haili
Choe, Vitnary
Bao, Xin
Shao, Jia
Luo, Shiwen
Rao, Hai
author_sort Baek, Guem Hee
collection PubMed
description Cdc48 (also called VCP and p97) is an abundant protein that plays essential regulatory functions in a broad array of cellular processes. Working with various cofactors, Cdc48 utilizes its ATPase activity to promote the assembly and disassembly of protein complexes. Here, we review key biological functions and regulation of Cdc48 in ubiquitin-related events. Given the broad employment of Cdc48 in cell biology and its intimate ties to human diseases (e.g., amyotrophic lateral sclerosis), studies of Cdc48 will bring significant insights into the mechanism and function of ubiquitin in health and diseases.
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spelling pubmed-37917972013-10-28 Cdc48: A Swiss Army Knife of Cell Biology Baek, Guem Hee Cheng, Haili Choe, Vitnary Bao, Xin Shao, Jia Luo, Shiwen Rao, Hai J Amino Acids Review Article Cdc48 (also called VCP and p97) is an abundant protein that plays essential regulatory functions in a broad array of cellular processes. Working with various cofactors, Cdc48 utilizes its ATPase activity to promote the assembly and disassembly of protein complexes. Here, we review key biological functions and regulation of Cdc48 in ubiquitin-related events. Given the broad employment of Cdc48 in cell biology and its intimate ties to human diseases (e.g., amyotrophic lateral sclerosis), studies of Cdc48 will bring significant insights into the mechanism and function of ubiquitin in health and diseases. Hindawi Publishing Corporation 2013 2013-09-15 /pmc/articles/PMC3791797/ /pubmed/24167726 http://dx.doi.org/10.1155/2013/183421 Text en Copyright © 2013 Guem Hee Baek et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Baek, Guem Hee
Cheng, Haili
Choe, Vitnary
Bao, Xin
Shao, Jia
Luo, Shiwen
Rao, Hai
Cdc48: A Swiss Army Knife of Cell Biology
title Cdc48: A Swiss Army Knife of Cell Biology
title_full Cdc48: A Swiss Army Knife of Cell Biology
title_fullStr Cdc48: A Swiss Army Knife of Cell Biology
title_full_unstemmed Cdc48: A Swiss Army Knife of Cell Biology
title_short Cdc48: A Swiss Army Knife of Cell Biology
title_sort cdc48: a swiss army knife of cell biology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791797/
https://www.ncbi.nlm.nih.gov/pubmed/24167726
http://dx.doi.org/10.1155/2013/183421
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