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Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction

Uterine leiomyomas (fibroids or myomas) are benign tumors of uterus and clinically apparent in a large part of reproductive aged women. Clinically, they present with a variety of symptoms: excessive menstrual bleeding, dysmenorrhoea and intermenstrual bleeding, chronic pelvic pain, and pressure symp...

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Autores principales: Ciavattini, Andrea, Di Giuseppe, Jacopo, Stortoni, Piergiorgio, Montik, Nina, Giannubilo, Stefano R., Litta, Pietro, Islam, Md. Soriful, Tranquilli, Andrea L., Reis, Fernando M., Ciarmela, Pasquapina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791844/
https://www.ncbi.nlm.nih.gov/pubmed/24163697
http://dx.doi.org/10.1155/2013/173184
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author Ciavattini, Andrea
Di Giuseppe, Jacopo
Stortoni, Piergiorgio
Montik, Nina
Giannubilo, Stefano R.
Litta, Pietro
Islam, Md. Soriful
Tranquilli, Andrea L.
Reis, Fernando M.
Ciarmela, Pasquapina
author_facet Ciavattini, Andrea
Di Giuseppe, Jacopo
Stortoni, Piergiorgio
Montik, Nina
Giannubilo, Stefano R.
Litta, Pietro
Islam, Md. Soriful
Tranquilli, Andrea L.
Reis, Fernando M.
Ciarmela, Pasquapina
author_sort Ciavattini, Andrea
collection PubMed
description Uterine leiomyomas (fibroids or myomas) are benign tumors of uterus and clinically apparent in a large part of reproductive aged women. Clinically, they present with a variety of symptoms: excessive menstrual bleeding, dysmenorrhoea and intermenstrual bleeding, chronic pelvic pain, and pressure symptoms such as a sensation of bloatedness, increased urinary frequency, and bowel disturbance. In addition, they may compromise reproductive functions, possibly contributing to subfertility, early pregnancy loss, and later pregnancy complications. Despite the prevalence of this condition, myoma research is underfunded compared to other nonmalignant diseases. To date, several pathogenetic factors such as genetics, microRNA, steroids, growth factors, cytokines, chemokines, and extracellular matrix components have been implicated in the development and growth of leiomyoma. This paper summarizes the available literature regarding the ultimate relative knowledge on pathogenesis of uterine fibroids and their interactions with endometrium and subendometrial myometrium.
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spelling pubmed-37918442013-10-27 Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction Ciavattini, Andrea Di Giuseppe, Jacopo Stortoni, Piergiorgio Montik, Nina Giannubilo, Stefano R. Litta, Pietro Islam, Md. Soriful Tranquilli, Andrea L. Reis, Fernando M. Ciarmela, Pasquapina Obstet Gynecol Int Review Article Uterine leiomyomas (fibroids or myomas) are benign tumors of uterus and clinically apparent in a large part of reproductive aged women. Clinically, they present with a variety of symptoms: excessive menstrual bleeding, dysmenorrhoea and intermenstrual bleeding, chronic pelvic pain, and pressure symptoms such as a sensation of bloatedness, increased urinary frequency, and bowel disturbance. In addition, they may compromise reproductive functions, possibly contributing to subfertility, early pregnancy loss, and later pregnancy complications. Despite the prevalence of this condition, myoma research is underfunded compared to other nonmalignant diseases. To date, several pathogenetic factors such as genetics, microRNA, steroids, growth factors, cytokines, chemokines, and extracellular matrix components have been implicated in the development and growth of leiomyoma. This paper summarizes the available literature regarding the ultimate relative knowledge on pathogenesis of uterine fibroids and their interactions with endometrium and subendometrial myometrium. Hindawi Publishing Corporation 2013 2013-09-12 /pmc/articles/PMC3791844/ /pubmed/24163697 http://dx.doi.org/10.1155/2013/173184 Text en Copyright © 2013 Andrea Ciavattini et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ciavattini, Andrea
Di Giuseppe, Jacopo
Stortoni, Piergiorgio
Montik, Nina
Giannubilo, Stefano R.
Litta, Pietro
Islam, Md. Soriful
Tranquilli, Andrea L.
Reis, Fernando M.
Ciarmela, Pasquapina
Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction
title Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction
title_full Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction
title_fullStr Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction
title_full_unstemmed Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction
title_short Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction
title_sort uterine fibroids: pathogenesis and interactions with endometrium and endomyometrial junction
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791844/
https://www.ncbi.nlm.nih.gov/pubmed/24163697
http://dx.doi.org/10.1155/2013/173184
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