Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug

Gatifloxacin is an antibacterial agent belonging to the fourth-generation fluoroquinolone family. Four piperazine-linked fluoroquinolone dimers of Gatifloxacin were observed during the laboratory process for Gatifloxacin and they were identified. The present work describes the origin, synthesis, cha...

Descripción completa

Detalles Bibliográficos
Autores principales: Garaga, Srinivas, Raghava Reddy, Ambati V., Prabahar, Koilpillai Joseph, Korupolu, Raghu Babu, Sanasi, Paul Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791930/
https://www.ncbi.nlm.nih.gov/pubmed/24106664
http://dx.doi.org/10.3797/scipharm.1212-21
Descripción
Sumario:Gatifloxacin is an antibacterial agent belonging to the fourth-generation fluoroquinolone family. Four piperazine-linked fluoroquinolone dimers of Gatifloxacin were observed during the laboratory process for Gatifloxacin and they were identified. The present work describes the origin, synthesis, characterization, and control of these dimers along with the synthesis of Despropylene Gatifloxacin (metabolite).

Ejemplares similares