Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity

Anticancer screening of several 1,2,3-triazoles with heterocyclic fragments has been performed. The 1,2,3-triazole derivatives were synthesized from available starting materials according to convenient synthetic procedures. The antitumor activity of the synthesized compounds was tested in vitro by t...

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Detalles Bibliográficos
Autores principales: Pokhodylo, Nazariy, Shyyka, Olga, Matiychuk, Vasyl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791931/
https://www.ncbi.nlm.nih.gov/pubmed/24106665
http://dx.doi.org/10.3797/scipharm.1302-04
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author Pokhodylo, Nazariy
Shyyka, Olga
Matiychuk, Vasyl
author_facet Pokhodylo, Nazariy
Shyyka, Olga
Matiychuk, Vasyl
author_sort Pokhodylo, Nazariy
collection PubMed
description Anticancer screening of several 1,2,3-triazoles with heterocyclic fragments has been performed. The 1,2,3-triazole derivatives were synthesized from available starting materials according to convenient synthetic procedures. The antitumor activity of the synthesized compounds was tested in vitro by the National Cancer Institute in NCI60 cell lines. It was observed that some compounds showed slight anticancer activity. One of them possessed a moderate activity against melanoma, colon, and breast cancer. Standard COMPARE analysis was performed at the GI(50) level.
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spelling pubmed-37919312013-10-08 Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity Pokhodylo, Nazariy Shyyka, Olga Matiychuk, Vasyl Sci Pharm Research Article Anticancer screening of several 1,2,3-triazoles with heterocyclic fragments has been performed. The 1,2,3-triazole derivatives were synthesized from available starting materials according to convenient synthetic procedures. The antitumor activity of the synthesized compounds was tested in vitro by the National Cancer Institute in NCI60 cell lines. It was observed that some compounds showed slight anticancer activity. One of them possessed a moderate activity against melanoma, colon, and breast cancer. Standard COMPARE analysis was performed at the GI(50) level. Österreichische Apotheker-Verlagsgesellschaft 2013 2013-04-14 /pmc/articles/PMC3791931/ /pubmed/24106665 http://dx.doi.org/10.3797/scipharm.1302-04 Text en © Pokhodylo et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pokhodylo, Nazariy
Shyyka, Olga
Matiychuk, Vasyl
Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity
title Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity
title_full Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity
title_fullStr Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity
title_full_unstemmed Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity
title_short Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity
title_sort synthesis of 1,2,3-triazole derivatives and evaluation of their anticancer activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791931/
https://www.ncbi.nlm.nih.gov/pubmed/24106665
http://dx.doi.org/10.3797/scipharm.1302-04
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AT shyykaolga synthesisof123triazolederivativesandevaluationoftheiranticanceractivity
AT matiychukvasyl synthesisof123triazolederivativesandevaluationoftheiranticanceractivity

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