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Microcirculatory Rarefaction in South Asians — A Potential Mechanism for Increased Cardiovascular Risk and Diabetes

People of South Asian descent have an increased risk of cardiovascular disease (CVD) and diabetes, but little is known about the microcirculation in South Asian people despite evidence that this plays an important role in the aetiology of CVD. We compared the retinal microcirculation in a population...

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Autores principales: Hughes, Alun D., Bathula, Raj, Park, Chloe, Tillin, Therese, Wit, Nicholas, McG Thom, Simon, Chaturvedi, Nish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792020/
https://www.ncbi.nlm.nih.gov/pubmed/24116136
http://dx.doi.org/10.1371/journal.pone.0076680
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author Hughes, Alun D.
Bathula, Raj
Park, Chloe
Tillin, Therese
Wit, Nicholas
McG Thom, Simon
Chaturvedi, Nish
author_facet Hughes, Alun D.
Bathula, Raj
Park, Chloe
Tillin, Therese
Wit, Nicholas
McG Thom, Simon
Chaturvedi, Nish
author_sort Hughes, Alun D.
collection PubMed
description People of South Asian descent have an increased risk of cardiovascular disease (CVD) and diabetes, but little is known about the microcirculation in South Asian people despite evidence that this plays an important role in the aetiology of CVD. We compared the retinal microcirculation in a population-based sample of 287 middle-aged adults (144 European 143 South Asian) matched for age and sex. Retinal photographs were taken and analysed using a validated semi-automated program and microvascular measures were compared. Blood pressure, anthropometry and fasting bloods were also measured. South Asians had significantly fewer arteriolar and venular vessels and bifurcations. Arterioles and venules were longer and venules were also more tortuous in South Asians. These differences were not explained by adjustment for traditional risk factors including blood pressure, body mass index, diabetes or measures of insulin resistance. People of South Asian descent have rarefaction of the retinal microcirculation compared to age-sex matched individuals of European descent. Reduced microvascular density could contribute to the elevated risk of CVD and impaired glucose tolerance in South Asian people.
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spelling pubmed-37920202013-10-10 Microcirculatory Rarefaction in South Asians — A Potential Mechanism for Increased Cardiovascular Risk and Diabetes Hughes, Alun D. Bathula, Raj Park, Chloe Tillin, Therese Wit, Nicholas McG Thom, Simon Chaturvedi, Nish PLoS One Research Article People of South Asian descent have an increased risk of cardiovascular disease (CVD) and diabetes, but little is known about the microcirculation in South Asian people despite evidence that this plays an important role in the aetiology of CVD. We compared the retinal microcirculation in a population-based sample of 287 middle-aged adults (144 European 143 South Asian) matched for age and sex. Retinal photographs were taken and analysed using a validated semi-automated program and microvascular measures were compared. Blood pressure, anthropometry and fasting bloods were also measured. South Asians had significantly fewer arteriolar and venular vessels and bifurcations. Arterioles and venules were longer and venules were also more tortuous in South Asians. These differences were not explained by adjustment for traditional risk factors including blood pressure, body mass index, diabetes or measures of insulin resistance. People of South Asian descent have rarefaction of the retinal microcirculation compared to age-sex matched individuals of European descent. Reduced microvascular density could contribute to the elevated risk of CVD and impaired glucose tolerance in South Asian people. Public Library of Science 2013-10-07 /pmc/articles/PMC3792020/ /pubmed/24116136 http://dx.doi.org/10.1371/journal.pone.0076680 Text en © 2013 Hughes et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hughes, Alun D.
Bathula, Raj
Park, Chloe
Tillin, Therese
Wit, Nicholas
McG Thom, Simon
Chaturvedi, Nish
Microcirculatory Rarefaction in South Asians — A Potential Mechanism for Increased Cardiovascular Risk and Diabetes
title Microcirculatory Rarefaction in South Asians — A Potential Mechanism for Increased Cardiovascular Risk and Diabetes
title_full Microcirculatory Rarefaction in South Asians — A Potential Mechanism for Increased Cardiovascular Risk and Diabetes
title_fullStr Microcirculatory Rarefaction in South Asians — A Potential Mechanism for Increased Cardiovascular Risk and Diabetes
title_full_unstemmed Microcirculatory Rarefaction in South Asians — A Potential Mechanism for Increased Cardiovascular Risk and Diabetes
title_short Microcirculatory Rarefaction in South Asians — A Potential Mechanism for Increased Cardiovascular Risk and Diabetes
title_sort microcirculatory rarefaction in south asians — a potential mechanism for increased cardiovascular risk and diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792020/
https://www.ncbi.nlm.nih.gov/pubmed/24116136
http://dx.doi.org/10.1371/journal.pone.0076680
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