A Remote Palm Domain Residue of RB69 DNA Polymerase Is Critical for Enzyme Activity and Influences the Conformation of the Active Site

Non-conserved amino acids that are far removed from the active site can sometimes have an unexpected effect on enzyme catalysis. We have investigated the effects of alanine replacement of residues distant from the active site of the replicative RB69 DNA polymerase, and identified a substitution in a...

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Detalles Bibliográficos
Autores principales: Jacewicz, Agata, Trzemecka, Anna, Guja, Kip E., Plochocka, Danuta, Yakubovskaya, Elena, Bebenek, Anna, Garcia-Diaz, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792054/
https://www.ncbi.nlm.nih.gov/pubmed/24116139
http://dx.doi.org/10.1371/journal.pone.0076700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792054/
https://www.ncbi.nlm.nih.gov/pubmed/24116139
http://dx.doi.org/10.1371/journal.pone.0076700

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