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Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS

The detection of cytosolic DNA, derived from pathogens or host cells, by cytosolic receptors is essential for appropriate host immune responses. Cyclic GMP-AMP synthase (cGAS) is a newly identified cytosolic DNA receptor that produces cyclic GMP-AMP, which activates stimulator of interferon genes (S...

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Detalles Bibliográficos
Autores principales:	Kato, Kazuki, Ishii, Ryohei, Goto, Eiji, Ishitani, Ryuichiro, Tokunaga, Fuminori, Nureki, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792152/ https://www.ncbi.nlm.nih.gov/pubmed/24116191 http://dx.doi.org/10.1371/journal.pone.0076983

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