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Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model
The fruit of Terminalia chebula Retzius has been used as a panacea in India and Southeast Asia but its biological activities have not been fully elucidated. Here we report anti-arthritic and analgesic effect of NDI10218, a standardized ethanol extract of Terminalia chebula, on collagen-induced arthr...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Applied Pharmacology
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792193/ https://www.ncbi.nlm.nih.gov/pubmed/24116282 http://dx.doi.org/10.4062/biomolther.2012.20.1.104 |
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author | Seo, Jong Bae Jeong, Jae-Yeon Park, Jae Young Jun, Eun Mi Lee, Sang-Ik Choe, Sung Sik Park, Do-Yang Choi, Eun-Wook Seen, Dong-Seung Lim, Jong-Soon Lee, Tae Gyu |
author_facet | Seo, Jong Bae Jeong, Jae-Yeon Park, Jae Young Jun, Eun Mi Lee, Sang-Ik Choe, Sung Sik Park, Do-Yang Choi, Eun-Wook Seen, Dong-Seung Lim, Jong-Soon Lee, Tae Gyu |
author_sort | Seo, Jong Bae |
collection | PubMed |
description | The fruit of Terminalia chebula Retzius has been used as a panacea in India and Southeast Asia but its biological activities have not been fully elucidated. Here we report anti-arthritic and analgesic effect of NDI10218, a standardized ethanol extract of Terminalia chebula, on collagen-induced arthritis and acetic acid-induced writhing model, respectively. Arthritis was induced in DBA/1J mice by immunizing bovine type II collagen and mice were treated with NDI10218 daily for 5 weeks after the onset of the disease. NDI10218 reduced the arthritis index and blocked the synovial hyperplasia in a dose-dependent manner. The serum levels of pro-inflammatory cytokines TNF-α, IL-6, and IL-1β were significantly reduced in mice treated with NDI10218. Production of the inflammatory IL-17, but not immunosuppressive IL-10, was also inhibited in splenocytes isolated from NDI10218-treated arthritis mice. Administration of NDI10218 markedly decreased the number of T cell subpopulations in the regional lymph nodes of the arthritis mice. Finally, NDI10218 reduced the number of abdominal contractions in acetic acid-induced writhing model, suggesting an analgesic effect of this extract. Taken together, these results suggest that NDI10218 can be a new therapeutic candidate for the treatment of rheuma-toid arthritis. |
format | Online Article Text |
id | pubmed-3792193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Society of Applied Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-37921932013-10-10 Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model Seo, Jong Bae Jeong, Jae-Yeon Park, Jae Young Jun, Eun Mi Lee, Sang-Ik Choe, Sung Sik Park, Do-Yang Choi, Eun-Wook Seen, Dong-Seung Lim, Jong-Soon Lee, Tae Gyu Biomol Ther (Seoul) Articles The fruit of Terminalia chebula Retzius has been used as a panacea in India and Southeast Asia but its biological activities have not been fully elucidated. Here we report anti-arthritic and analgesic effect of NDI10218, a standardized ethanol extract of Terminalia chebula, on collagen-induced arthritis and acetic acid-induced writhing model, respectively. Arthritis was induced in DBA/1J mice by immunizing bovine type II collagen and mice were treated with NDI10218 daily for 5 weeks after the onset of the disease. NDI10218 reduced the arthritis index and blocked the synovial hyperplasia in a dose-dependent manner. The serum levels of pro-inflammatory cytokines TNF-α, IL-6, and IL-1β were significantly reduced in mice treated with NDI10218. Production of the inflammatory IL-17, but not immunosuppressive IL-10, was also inhibited in splenocytes isolated from NDI10218-treated arthritis mice. Administration of NDI10218 markedly decreased the number of T cell subpopulations in the regional lymph nodes of the arthritis mice. Finally, NDI10218 reduced the number of abdominal contractions in acetic acid-induced writhing model, suggesting an analgesic effect of this extract. Taken together, these results suggest that NDI10218 can be a new therapeutic candidate for the treatment of rheuma-toid arthritis. The Korean Society of Applied Pharmacology 2012-01 /pmc/articles/PMC3792193/ /pubmed/24116282 http://dx.doi.org/10.4062/biomolther.2012.20.1.104 Text en Copyright ©2012, The Korean Society of Applied Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Seo, Jong Bae Jeong, Jae-Yeon Park, Jae Young Jun, Eun Mi Lee, Sang-Ik Choe, Sung Sik Park, Do-Yang Choi, Eun-Wook Seen, Dong-Seung Lim, Jong-Soon Lee, Tae Gyu Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model |
title | Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model |
title_full | Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model |
title_fullStr | Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model |
title_full_unstemmed | Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model |
title_short | Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model |
title_sort | anti-arthritic and analgesic effect of ndi10218, a standardized extract of terminalia chebula, on arthritis and pain model |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792193/ https://www.ncbi.nlm.nih.gov/pubmed/24116282 http://dx.doi.org/10.4062/biomolther.2012.20.1.104 |
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