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Cerebellar cortical neuron responses evoked from the spinal border cell tract

Spinocerebellar systems are likely to be crucial for cerebellar hallmark functions such as coordination. However, in terms of cerebellar functional analyses, these are perhaps among the least explored systems. The aim of the present study is to achieve activation of a single component of the spinoce...

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Autores principales: Geborek, Pontus, Spanne, Anton, Bengtsson, Fredrik, Jörntell, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792349/
https://www.ncbi.nlm.nih.gov/pubmed/24115921
http://dx.doi.org/10.3389/fncir.2013.00157
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author Geborek, Pontus
Spanne, Anton
Bengtsson, Fredrik
Jörntell, Henrik
author_facet Geborek, Pontus
Spanne, Anton
Bengtsson, Fredrik
Jörntell, Henrik
author_sort Geborek, Pontus
collection PubMed
description Spinocerebellar systems are likely to be crucial for cerebellar hallmark functions such as coordination. However, in terms of cerebellar functional analyses, these are perhaps among the least explored systems. The aim of the present study is to achieve activation of a single component of the spinocerebellar systems and to explore to what extent it can influence the spike output of granule cells, Golgi cells, molecular layer (ML) interneurons (stellate and basket cells) and Purkinje cells (PCs). For this purpose, we took advantage of a unique arrangement discovered in neuroanatomical studies, in which the spinal border cell (SBC) component of the ventral spinocerebellar system was found to be the only spinocerebellar tract which ascends in the contralateral lateral funiculus (coLF) and have terminations in sublobulus C1 of the paramedian lobule in the posterior cerebellum. Using electrical stimulation of this tract, we find a subset of the cerebellar cortical neurons in this region to be moderately or powerfully activated. For example, some of our granule cells displayed high intensity responses whereas the majority of the granule cells displayed no response at all. The finding that more than half of the PCs were activated by stimulation of the SBC tract indicated that this system is capable of directly influencing cerebellar cortical output. The implications of these findings for the view of the integrative functions of the cerebellar cortex are discussed.
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spelling pubmed-37923492013-10-10 Cerebellar cortical neuron responses evoked from the spinal border cell tract Geborek, Pontus Spanne, Anton Bengtsson, Fredrik Jörntell, Henrik Front Neural Circuits Neuroscience Spinocerebellar systems are likely to be crucial for cerebellar hallmark functions such as coordination. However, in terms of cerebellar functional analyses, these are perhaps among the least explored systems. The aim of the present study is to achieve activation of a single component of the spinocerebellar systems and to explore to what extent it can influence the spike output of granule cells, Golgi cells, molecular layer (ML) interneurons (stellate and basket cells) and Purkinje cells (PCs). For this purpose, we took advantage of a unique arrangement discovered in neuroanatomical studies, in which the spinal border cell (SBC) component of the ventral spinocerebellar system was found to be the only spinocerebellar tract which ascends in the contralateral lateral funiculus (coLF) and have terminations in sublobulus C1 of the paramedian lobule in the posterior cerebellum. Using electrical stimulation of this tract, we find a subset of the cerebellar cortical neurons in this region to be moderately or powerfully activated. For example, some of our granule cells displayed high intensity responses whereas the majority of the granule cells displayed no response at all. The finding that more than half of the PCs were activated by stimulation of the SBC tract indicated that this system is capable of directly influencing cerebellar cortical output. The implications of these findings for the view of the integrative functions of the cerebellar cortex are discussed. Frontiers Media S.A. 2013-10-08 /pmc/articles/PMC3792349/ /pubmed/24115921 http://dx.doi.org/10.3389/fncir.2013.00157 Text en Copyright © 2013 Geborek, Spanne, Bengtsson and Jörntell. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Geborek, Pontus
Spanne, Anton
Bengtsson, Fredrik
Jörntell, Henrik
Cerebellar cortical neuron responses evoked from the spinal border cell tract
title Cerebellar cortical neuron responses evoked from the spinal border cell tract
title_full Cerebellar cortical neuron responses evoked from the spinal border cell tract
title_fullStr Cerebellar cortical neuron responses evoked from the spinal border cell tract
title_full_unstemmed Cerebellar cortical neuron responses evoked from the spinal border cell tract
title_short Cerebellar cortical neuron responses evoked from the spinal border cell tract
title_sort cerebellar cortical neuron responses evoked from the spinal border cell tract
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792349/
https://www.ncbi.nlm.nih.gov/pubmed/24115921
http://dx.doi.org/10.3389/fncir.2013.00157
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