Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage

Extracellular hemoglobin (Hb) has been recognized as a disease trigger in hemolytic conditions such as sickle cell disease, malaria, and blood transfusion. In vivo, many of the adverse effects of free Hb can be attenuated by the Hb scavenger acute-phase protein haptoglobin (Hp). The primary physiolo...

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Detalles Bibliográficos
Autores principales: Schaer, C A, Deuel, J W, Bittermann, A G, Rubio, I G, Schoedon, G, Spahn, D R, Wepf, R A, Vallelian, F, Schaer, D J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792434/
https://www.ncbi.nlm.nih.gov/pubmed/23995229
http://dx.doi.org/10.1038/cdd.2013.113

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