Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

Somatic mutations in the isocitrate dehydrogenase (IDH) genes IDH1 and IDH2 occur frequently in acute myeloid leukemia (AML) and other cancers. These genes encode neomorphic proteins that produce the presumed oncometabolite 2-hydroxyglutarate (2-HG). Despite the prospect of treating AML and other ca...

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Detalles Bibliográficos
Autores principales: Chen, Chong, Liu, Yu, Lu, Chao, Cross, Justin R., Morris, John P., Shroff, Aditya S., Ward, Patrick S., Bradner, James E., Thompson, Craig, Lowe, Scott W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792474/
https://www.ncbi.nlm.nih.gov/pubmed/24065765
http://dx.doi.org/10.1101/gad.226613.113

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