Induction of sarcomas by mutant IDH2

More than 50% of patients with chondrosarcomas exhibit gain-of-function mutations in either isocitrate dehydrogenase 1 (IDH1) or IDH2. In this study, we performed genome-wide CpG methylation sequencing of chondrosarcoma biopsies and found that IDH mutations were associated with DNA hypermethylation...

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Detalles Bibliográficos
Autores principales: Lu, Chao, Venneti, Sriram, Akalin, Altuna, Fang, Fang, Ward, Patrick S., DeMatteo, Raymond G., Intlekofer, Andrew M., Chen, Chong, Ye, Jiangbin, Hameed, Meera, Nafa, Khedoudja, Agaram, Narasimhan P., Cross, Justin R., Khanin, Raya, Mason, Christopher E., Healey, John H., Lowe, Scott W., Schwartz, Gary K., Melnick, Ari, Thompson, Craig B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792475/
https://www.ncbi.nlm.nih.gov/pubmed/24065766
http://dx.doi.org/10.1101/gad.226753.113

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