Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion

We describe three confirmed cases of squamous cell carcinoma (SCC) of the lung with metastasis to the gastrointestinal (GI) tract, with two having epidermal growth factor receptor (EGFR) exon 19 deletions in all available specimens. One of these patients received EGFR tyrosine kinase directed therap...

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Autores principales: Weiss, Glen J., Liman, Agnes K., Allen, Jeffrey, Cheung, Philip Y., Kukunoor, Rajesh N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792501/
https://www.ncbi.nlm.nih.gov/pubmed/24171005
http://dx.doi.org/10.1155/2013/874836
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author Weiss, Glen J.
Liman, Agnes K.
Allen, Jeffrey
Cheung, Philip Y.
Kukunoor, Rajesh N.
author_facet Weiss, Glen J.
Liman, Agnes K.
Allen, Jeffrey
Cheung, Philip Y.
Kukunoor, Rajesh N.
author_sort Weiss, Glen J.
collection PubMed
description We describe three confirmed cases of squamous cell carcinoma (SCC) of the lung with metastasis to the gastrointestinal (GI) tract, with two having epidermal growth factor receptor (EGFR) exon 19 deletions in all available specimens. One of these patients received EGFR tyrosine kinase directed therapy for a brief period with some symptom relief. Consideration of EGFR exon 19 mutation testing in SCC of the lung, particularly for those with GI tract metastasis, may identify this potentially drug-targetable entity.
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spelling pubmed-37925012013-10-29 Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion Weiss, Glen J. Liman, Agnes K. Allen, Jeffrey Cheung, Philip Y. Kukunoor, Rajesh N. Case Rep Med Case Report We describe three confirmed cases of squamous cell carcinoma (SCC) of the lung with metastasis to the gastrointestinal (GI) tract, with two having epidermal growth factor receptor (EGFR) exon 19 deletions in all available specimens. One of these patients received EGFR tyrosine kinase directed therapy for a brief period with some symptom relief. Consideration of EGFR exon 19 mutation testing in SCC of the lung, particularly for those with GI tract metastasis, may identify this potentially drug-targetable entity. Hindawi Publishing Corporation 2013 2013-09-19 /pmc/articles/PMC3792501/ /pubmed/24171005 http://dx.doi.org/10.1155/2013/874836 Text en Copyright © 2013 Glen J. Weiss et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Weiss, Glen J.
Liman, Agnes K.
Allen, Jeffrey
Cheung, Philip Y.
Kukunoor, Rajesh N.
Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion
title Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion
title_full Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion
title_fullStr Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion
title_full_unstemmed Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion
title_short Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion
title_sort squamous cell carcinoma of the lung with metastasis to the gi tract associated with egfr exon 19 deletion
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792501/
https://www.ncbi.nlm.nih.gov/pubmed/24171005
http://dx.doi.org/10.1155/2013/874836
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