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Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria

Highly ionic metal oxide nanostructures are attractive, not only for their physiochemical properties but also for antibacterial activity. Zinc oxide (ZnO) nanostructures are known to have inhibitory activity against many pathogens but very little is known about doping effects on it. The antibacteria...

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Autores principales: Jan, Tariq, Iqbal, Javed, Ismail, Muhammad, Zakaullah, M, Naqvi, Sajjad Haider, Badshah, Noor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792850/
https://www.ncbi.nlm.nih.gov/pubmed/24109181
http://dx.doi.org/10.2147/IJN.S45439
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author Jan, Tariq
Iqbal, Javed
Ismail, Muhammad
Zakaullah, M
Naqvi, Sajjad Haider
Badshah, Noor
author_facet Jan, Tariq
Iqbal, Javed
Ismail, Muhammad
Zakaullah, M
Naqvi, Sajjad Haider
Badshah, Noor
author_sort Jan, Tariq
collection PubMed
description Highly ionic metal oxide nanostructures are attractive, not only for their physiochemical properties but also for antibacterial activity. Zinc oxide (ZnO) nanostructures are known to have inhibitory activity against many pathogens but very little is known about doping effects on it. The antibacterial activity of undoped ZnO and tin (Sn) doped ZnO nanostructures synthesized by a simple, versatile, and wet chemical technique have been investigated against Escherichia coli, methicillin-resistant Staphylococcus aureus, and Pseudomonas aeruginosa bacterial strains. It has been interestingly observed that Sn doping enhanced the inhibitory activity of ZnO against S. aureus more efficiently than the other two bacterial strains. From cytotoxicity and reactive oxygen species (ROS) production studies it is found that Sn doping concentration in ZnO does not alter the cytotoxicity and ROS production very much. It has also been observed that undoped and Sn doped ZnO nanostructures are biosafe and biocompatible materials towards SH-SY5Y Cells. The observed behavior of ZnO nanostructures with Sn doping is a new way to prevent bacterial infections of S. aureus, especially on skin, when using these nanostructures in creams or lotions in addition to their sunscreen property as an ultraviolet filter. Structural investigations have confirmed the formation of a single phase wurtzite structure of ZnO. The morphology of ZnO nanostructures is found to vary from spherical to rod shaped as a function of Sn doping. The excitation absorption peak of ZnO is observed to have a blue shift, with Sn doping leading toward a significant tuning in band gap.
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spelling pubmed-37928502013-10-09 Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria Jan, Tariq Iqbal, Javed Ismail, Muhammad Zakaullah, M Naqvi, Sajjad Haider Badshah, Noor Int J Nanomedicine Original Research Highly ionic metal oxide nanostructures are attractive, not only for their physiochemical properties but also for antibacterial activity. Zinc oxide (ZnO) nanostructures are known to have inhibitory activity against many pathogens but very little is known about doping effects on it. The antibacterial activity of undoped ZnO and tin (Sn) doped ZnO nanostructures synthesized by a simple, versatile, and wet chemical technique have been investigated against Escherichia coli, methicillin-resistant Staphylococcus aureus, and Pseudomonas aeruginosa bacterial strains. It has been interestingly observed that Sn doping enhanced the inhibitory activity of ZnO against S. aureus more efficiently than the other two bacterial strains. From cytotoxicity and reactive oxygen species (ROS) production studies it is found that Sn doping concentration in ZnO does not alter the cytotoxicity and ROS production very much. It has also been observed that undoped and Sn doped ZnO nanostructures are biosafe and biocompatible materials towards SH-SY5Y Cells. The observed behavior of ZnO nanostructures with Sn doping is a new way to prevent bacterial infections of S. aureus, especially on skin, when using these nanostructures in creams or lotions in addition to their sunscreen property as an ultraviolet filter. Structural investigations have confirmed the formation of a single phase wurtzite structure of ZnO. The morphology of ZnO nanostructures is found to vary from spherical to rod shaped as a function of Sn doping. The excitation absorption peak of ZnO is observed to have a blue shift, with Sn doping leading toward a significant tuning in band gap. Dove Medical Press 2013 2013-09-30 /pmc/articles/PMC3792850/ /pubmed/24109181 http://dx.doi.org/10.2147/IJN.S45439 Text en © 2013 Jan et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Jan, Tariq
Iqbal, Javed
Ismail, Muhammad
Zakaullah, M
Naqvi, Sajjad Haider
Badshah, Noor
Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria
title Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria
title_full Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria
title_fullStr Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria
title_full_unstemmed Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria
title_short Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria
title_sort sn doping induced enhancement in the activity of zno nanostructures against antibiotic resistant s. aureus bacteria
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792850/
https://www.ncbi.nlm.nih.gov/pubmed/24109181
http://dx.doi.org/10.2147/IJN.S45439
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