New structure–activity relationships of chalcone inhibitors of breast cancer resistance protein: polyspecificity toward inhibition and critical substitutions against cytotoxicity

Adenosine triphosphate-binding cassette subfamily G member 2 (ABCG2) plays a major role in cancer cell multidrug resistance, which contributes to low eifficacy of chemotherapy. Chalcones were recently found to be potent and specific inhibitors, but unfortunately display a significant cytotoxicity. A...

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Detalles Bibliográficos
Autores principales: Rangel, Luciana Pereira, Winter, Evelyn, Gauthier, Charlotte, Terreux, Raphaël, Chiaradia-Delatorre, Louise D, Mascarello, Alessandra, Nunes, Ricardo J, Yunes, Rosendo A, Creczynski-Pasa, Tania B, Macalou, Sira, Lorendeau, Doriane, Baubichon-Cortay, Hélène, Ferreira-Pereira, Antonio, Di Pietro, Attilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792851/
https://www.ncbi.nlm.nih.gov/pubmed/24109177
http://dx.doi.org/10.2147/DDDT.S46983

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