Variation in One Residue Associated with the Metal Ion-Dependent Adhesion Site Regulates αIIbβ3 Integrin Ligand Binding Affinity

The Asp of the RGD motif of the ligand coordinates with the β I domain metal ion dependent adhesion site (MIDAS) divalent cation, emphasizing the importance of the MIDAS in ligand binding. There appears to be two distinct groups of integrins that differ in their ligand binding affinity and adhesion...

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Detalles Bibliográficos
Autores principales: Raborn, Joel, Fu, Ting, Wu, Xue, Xiu, Zhilong, Li, Guohui, Luo, Bing-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792891/
https://www.ncbi.nlm.nih.gov/pubmed/24116162
http://dx.doi.org/10.1371/journal.pone.0076793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792891/
https://www.ncbi.nlm.nih.gov/pubmed/24116162
http://dx.doi.org/10.1371/journal.pone.0076793

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