Multiple Protein Domains Contribute to Nuclear Import and Cell Toxicity of DUX4, a Candidate Pathogenic Protein for Facioscapulohumeral Muscular Dystrophy

DUX4 (Double Homeobox Protein 4) is a nuclear transcription factor encoded at each D4Z4 unit of a tandem-repeat array at human chromosome 4q35. DUX4 constitutes a major candidate pathogenic protein for facioscapulohumeral muscular dystrophy (FSHD), the third most common form of inherited myopathy. A...

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Detalles Bibliográficos
Autores principales: Corona, Edgardo Daniel, Jacquelin, Daniela, Gatica, Laura, Rosa, Alberto Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792938/
https://www.ncbi.nlm.nih.gov/pubmed/24116060
http://dx.doi.org/10.1371/journal.pone.0075614

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