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A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity
RNA interference defends against viral infection in plant and animal cells. The nematode Caenorhabditis elegans and its natural pathogen, the positive-strand RNA virus Orsay, have recently emerged as a new animal model of host-virus interaction. Using a genome-wide association study in C. elegans wi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793227/ https://www.ncbi.nlm.nih.gov/pubmed/24137537 http://dx.doi.org/10.7554/eLife.00994 |
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author | Ashe, Alyson Bélicard, Tony Le Pen, Jérémie Sarkies, Peter Frézal, Lise Lehrbach, Nicolas J Félix, Marie-Anne Miska, Eric A |
author_facet | Ashe, Alyson Bélicard, Tony Le Pen, Jérémie Sarkies, Peter Frézal, Lise Lehrbach, Nicolas J Félix, Marie-Anne Miska, Eric A |
author_sort | Ashe, Alyson |
collection | PubMed |
description | RNA interference defends against viral infection in plant and animal cells. The nematode Caenorhabditis elegans and its natural pathogen, the positive-strand RNA virus Orsay, have recently emerged as a new animal model of host-virus interaction. Using a genome-wide association study in C. elegans wild populations and quantitative trait locus mapping, we identify a 159 base-pair deletion in the conserved drh-1 gene (encoding a RIG-I-like helicase) as a major determinant of viral sensitivity. We show that DRH-1 is required for the initiation of an antiviral RNAi pathway and the generation of virus-derived siRNAs (viRNAs). In mammals, RIG-I-domain containing proteins trigger an interferon-based innate immunity pathway in response to RNA virus infection. Our work in C. elegans demonstrates that the RIG-I domain has an ancient role in viral recognition. We propose that RIG-I acts as modular viral recognition factor that couples viral recognition to different effector pathways including RNAi and interferon responses. DOI: http://dx.doi.org/10.7554/eLife.00994.001 |
format | Online Article Text |
id | pubmed-3793227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37932272013-10-17 A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity Ashe, Alyson Bélicard, Tony Le Pen, Jérémie Sarkies, Peter Frézal, Lise Lehrbach, Nicolas J Félix, Marie-Anne Miska, Eric A eLife Genomics and Evolutionary Biology RNA interference defends against viral infection in plant and animal cells. The nematode Caenorhabditis elegans and its natural pathogen, the positive-strand RNA virus Orsay, have recently emerged as a new animal model of host-virus interaction. Using a genome-wide association study in C. elegans wild populations and quantitative trait locus mapping, we identify a 159 base-pair deletion in the conserved drh-1 gene (encoding a RIG-I-like helicase) as a major determinant of viral sensitivity. We show that DRH-1 is required for the initiation of an antiviral RNAi pathway and the generation of virus-derived siRNAs (viRNAs). In mammals, RIG-I-domain containing proteins trigger an interferon-based innate immunity pathway in response to RNA virus infection. Our work in C. elegans demonstrates that the RIG-I domain has an ancient role in viral recognition. We propose that RIG-I acts as modular viral recognition factor that couples viral recognition to different effector pathways including RNAi and interferon responses. DOI: http://dx.doi.org/10.7554/eLife.00994.001 eLife Sciences Publications, Ltd 2013-10-08 /pmc/articles/PMC3793227/ /pubmed/24137537 http://dx.doi.org/10.7554/eLife.00994 Text en Copyright © 2013, Ashe et al http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Genomics and Evolutionary Biology Ashe, Alyson Bélicard, Tony Le Pen, Jérémie Sarkies, Peter Frézal, Lise Lehrbach, Nicolas J Félix, Marie-Anne Miska, Eric A A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity |
title | A deletion polymorphism in the Caenorhabditis
elegans RIG-I homolog disables viral RNA dicing and antiviral
immunity |
title_full | A deletion polymorphism in the Caenorhabditis
elegans RIG-I homolog disables viral RNA dicing and antiviral
immunity |
title_fullStr | A deletion polymorphism in the Caenorhabditis
elegans RIG-I homolog disables viral RNA dicing and antiviral
immunity |
title_full_unstemmed | A deletion polymorphism in the Caenorhabditis
elegans RIG-I homolog disables viral RNA dicing and antiviral
immunity |
title_short | A deletion polymorphism in the Caenorhabditis
elegans RIG-I homolog disables viral RNA dicing and antiviral
immunity |
title_sort | deletion polymorphism in the caenorhabditis
elegans rig-i homolog disables viral rna dicing and antiviral
immunity |
topic | Genomics and Evolutionary Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793227/ https://www.ncbi.nlm.nih.gov/pubmed/24137537 http://dx.doi.org/10.7554/eLife.00994 |
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