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Rose geranium essential oil as a source of new and safe anti-inflammatory drugs
BACKGROUND: Since the available anti-inflammatory drugs exert an extensive variety of side effects, the search for new anti-inflammatory agents has been a priority of pharmaceutical industries. AIMS: The aim of the present study was to assess the anti-inflammatory activities of the essential oil of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Co-Action Publishing
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793238/ https://www.ncbi.nlm.nih.gov/pubmed/24103319 http://dx.doi.org/10.3402/ljm.v8i0.22520 |
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author | Boukhatem, Mohamed Nadjib Kameli, Abdelkrim Ferhat, Mohamed Amine Saidi, Fairouz Mekarnia, Maamar |
author_facet | Boukhatem, Mohamed Nadjib Kameli, Abdelkrim Ferhat, Mohamed Amine Saidi, Fairouz Mekarnia, Maamar |
author_sort | Boukhatem, Mohamed Nadjib |
collection | PubMed |
description | BACKGROUND: Since the available anti-inflammatory drugs exert an extensive variety of side effects, the search for new anti-inflammatory agents has been a priority of pharmaceutical industries. AIMS: The aim of the present study was to assess the anti-inflammatory activities of the essential oil of rose geranium (RGEO). METHODS: The chemical composition of the RGEO was investigated by gas chromatography. The major components were citronellol (29.13%), geraniol (12.62%), and citronellyl formate (8.06%). In the carrageenan-induced paw edema, five different groups were established and RGEO was administered orally in three different doses. RESULTS: RGEO (100 mg/kg) was able to significantly reduce the paw edema with a comparable effect to that observed with diclofenac, the positive control. In addition, RGEO showed a potent anti-inflammatory activity by topical treatment in the method of croton oil-induced ear edema. When the dose was 5 or 10 µl of RGEO per ear, the inflammation was reduced by 73 and 88%, respectively. This is the first report to demonstrate a significant anti-inflammatory activity of Algerian RGEO. In addition, histological analysis confirmed that RGEO inhibited the inflammatory responses in the skin. CONCLUSION: Our results indicate that RGEO may have significant potential for the development of novel anti-inflammatory drugs with improved safety profile. |
format | Online Article Text |
id | pubmed-3793238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Co-Action Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-37932382013-10-09 Rose geranium essential oil as a source of new and safe anti-inflammatory drugs Boukhatem, Mohamed Nadjib Kameli, Abdelkrim Ferhat, Mohamed Amine Saidi, Fairouz Mekarnia, Maamar Libyan J Med Original Article BACKGROUND: Since the available anti-inflammatory drugs exert an extensive variety of side effects, the search for new anti-inflammatory agents has been a priority of pharmaceutical industries. AIMS: The aim of the present study was to assess the anti-inflammatory activities of the essential oil of rose geranium (RGEO). METHODS: The chemical composition of the RGEO was investigated by gas chromatography. The major components were citronellol (29.13%), geraniol (12.62%), and citronellyl formate (8.06%). In the carrageenan-induced paw edema, five different groups were established and RGEO was administered orally in three different doses. RESULTS: RGEO (100 mg/kg) was able to significantly reduce the paw edema with a comparable effect to that observed with diclofenac, the positive control. In addition, RGEO showed a potent anti-inflammatory activity by topical treatment in the method of croton oil-induced ear edema. When the dose was 5 or 10 µl of RGEO per ear, the inflammation was reduced by 73 and 88%, respectively. This is the first report to demonstrate a significant anti-inflammatory activity of Algerian RGEO. In addition, histological analysis confirmed that RGEO inhibited the inflammatory responses in the skin. CONCLUSION: Our results indicate that RGEO may have significant potential for the development of novel anti-inflammatory drugs with improved safety profile. Co-Action Publishing 2013-10-07 /pmc/articles/PMC3793238/ /pubmed/24103319 http://dx.doi.org/10.3402/ljm.v8i0.22520 Text en © 2013 Mohamed Nadjib Boukhatem et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Boukhatem, Mohamed Nadjib Kameli, Abdelkrim Ferhat, Mohamed Amine Saidi, Fairouz Mekarnia, Maamar Rose geranium essential oil as a source of new and safe anti-inflammatory drugs |
title | Rose geranium essential oil as a source of new and safe anti-inflammatory drugs |
title_full | Rose geranium essential oil as a source of new and safe anti-inflammatory drugs |
title_fullStr | Rose geranium essential oil as a source of new and safe anti-inflammatory drugs |
title_full_unstemmed | Rose geranium essential oil as a source of new and safe anti-inflammatory drugs |
title_short | Rose geranium essential oil as a source of new and safe anti-inflammatory drugs |
title_sort | rose geranium essential oil as a source of new and safe anti-inflammatory drugs |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793238/ https://www.ncbi.nlm.nih.gov/pubmed/24103319 http://dx.doi.org/10.3402/ljm.v8i0.22520 |
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