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Rose geranium essential oil as a source of new and safe anti-inflammatory drugs

BACKGROUND: Since the available anti-inflammatory drugs exert an extensive variety of side effects, the search for new anti-inflammatory agents has been a priority of pharmaceutical industries. AIMS: The aim of the present study was to assess the anti-inflammatory activities of the essential oil of...

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Autores principales: Boukhatem, Mohamed Nadjib, Kameli, Abdelkrim, Ferhat, Mohamed Amine, Saidi, Fairouz, Mekarnia, Maamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Co-Action Publishing 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793238/
https://www.ncbi.nlm.nih.gov/pubmed/24103319
http://dx.doi.org/10.3402/ljm.v8i0.22520
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author Boukhatem, Mohamed Nadjib
Kameli, Abdelkrim
Ferhat, Mohamed Amine
Saidi, Fairouz
Mekarnia, Maamar
author_facet Boukhatem, Mohamed Nadjib
Kameli, Abdelkrim
Ferhat, Mohamed Amine
Saidi, Fairouz
Mekarnia, Maamar
author_sort Boukhatem, Mohamed Nadjib
collection PubMed
description BACKGROUND: Since the available anti-inflammatory drugs exert an extensive variety of side effects, the search for new anti-inflammatory agents has been a priority of pharmaceutical industries. AIMS: The aim of the present study was to assess the anti-inflammatory activities of the essential oil of rose geranium (RGEO). METHODS: The chemical composition of the RGEO was investigated by gas chromatography. The major components were citronellol (29.13%), geraniol (12.62%), and citronellyl formate (8.06%). In the carrageenan-induced paw edema, five different groups were established and RGEO was administered orally in three different doses. RESULTS: RGEO (100 mg/kg) was able to significantly reduce the paw edema with a comparable effect to that observed with diclofenac, the positive control. In addition, RGEO showed a potent anti-inflammatory activity by topical treatment in the method of croton oil-induced ear edema. When the dose was 5 or 10 µl of RGEO per ear, the inflammation was reduced by 73 and 88%, respectively. This is the first report to demonstrate a significant anti-inflammatory activity of Algerian RGEO. In addition, histological analysis confirmed that RGEO inhibited the inflammatory responses in the skin. CONCLUSION: Our results indicate that RGEO may have significant potential for the development of novel anti-inflammatory drugs with improved safety profile.
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spelling pubmed-37932382013-10-09 Rose geranium essential oil as a source of new and safe anti-inflammatory drugs Boukhatem, Mohamed Nadjib Kameli, Abdelkrim Ferhat, Mohamed Amine Saidi, Fairouz Mekarnia, Maamar Libyan J Med Original Article BACKGROUND: Since the available anti-inflammatory drugs exert an extensive variety of side effects, the search for new anti-inflammatory agents has been a priority of pharmaceutical industries. AIMS: The aim of the present study was to assess the anti-inflammatory activities of the essential oil of rose geranium (RGEO). METHODS: The chemical composition of the RGEO was investigated by gas chromatography. The major components were citronellol (29.13%), geraniol (12.62%), and citronellyl formate (8.06%). In the carrageenan-induced paw edema, five different groups were established and RGEO was administered orally in three different doses. RESULTS: RGEO (100 mg/kg) was able to significantly reduce the paw edema with a comparable effect to that observed with diclofenac, the positive control. In addition, RGEO showed a potent anti-inflammatory activity by topical treatment in the method of croton oil-induced ear edema. When the dose was 5 or 10 µl of RGEO per ear, the inflammation was reduced by 73 and 88%, respectively. This is the first report to demonstrate a significant anti-inflammatory activity of Algerian RGEO. In addition, histological analysis confirmed that RGEO inhibited the inflammatory responses in the skin. CONCLUSION: Our results indicate that RGEO may have significant potential for the development of novel anti-inflammatory drugs with improved safety profile. Co-Action Publishing 2013-10-07 /pmc/articles/PMC3793238/ /pubmed/24103319 http://dx.doi.org/10.3402/ljm.v8i0.22520 Text en © 2013 Mohamed Nadjib Boukhatem et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Boukhatem, Mohamed Nadjib
Kameli, Abdelkrim
Ferhat, Mohamed Amine
Saidi, Fairouz
Mekarnia, Maamar
Rose geranium essential oil as a source of new and safe anti-inflammatory drugs
title Rose geranium essential oil as a source of new and safe anti-inflammatory drugs
title_full Rose geranium essential oil as a source of new and safe anti-inflammatory drugs
title_fullStr Rose geranium essential oil as a source of new and safe anti-inflammatory drugs
title_full_unstemmed Rose geranium essential oil as a source of new and safe anti-inflammatory drugs
title_short Rose geranium essential oil as a source of new and safe anti-inflammatory drugs
title_sort rose geranium essential oil as a source of new and safe anti-inflammatory drugs
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793238/
https://www.ncbi.nlm.nih.gov/pubmed/24103319
http://dx.doi.org/10.3402/ljm.v8i0.22520
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