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Thrombin induces epithelial-mesenchymal transition via PAR-1, PKC, and ERK1/2 pathways in A549 cells
Thrombin activates protease-activated receptor (PAR)-1 and induces a myofibroblast phenotype in normal lung fibroblasts. The origins of myofibroblasts are resident fibroblasts, fibrocytes, and epithelial-mesenchymal transition (EMT). We investigated the effects of thrombin, an important mediator of...
Autores principales: | Song, Jeong Sup, Kang, Chun Mi, Park, Chan Kwon, Yoon, Hyung Kyu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Informa Healthcare
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793269/ https://www.ncbi.nlm.nih.gov/pubmed/23919450 http://dx.doi.org/10.3109/01902148.2013.820809 |
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