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Biomedical and Clinical Promises of Human Pluripotent Stem Cells for Neurological Disorders

Neurological disorders are characterized by the chronic and progressive loss of neuronal structures and functions. There is a variability of the onsets and causes of clinical manifestations. Cell therapy has brought a new concept to overcome brain diseases, but the advancement of this therapy is lim...

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Detalles Bibliográficos
Autores principales: Jongkamonwiwat, Nopporn, Noisa, Parinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793324/
https://www.ncbi.nlm.nih.gov/pubmed/24171168
http://dx.doi.org/10.1155/2013/656531
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author Jongkamonwiwat, Nopporn
Noisa, Parinya
author_facet Jongkamonwiwat, Nopporn
Noisa, Parinya
author_sort Jongkamonwiwat, Nopporn
collection PubMed
description Neurological disorders are characterized by the chronic and progressive loss of neuronal structures and functions. There is a variability of the onsets and causes of clinical manifestations. Cell therapy has brought a new concept to overcome brain diseases, but the advancement of this therapy is limited by the demands of specialized neurons. Human pluripotent stem cells (hPSCs) have been promised as a renewable resource for generating human neurons for both laboratory and clinical purposes. By the modulations of appropriate signalling pathways, desired neuron subtypes can be obtained, and induced pluripotent stem cells (iPSCs) provide genetically matched neurons for treating patients. These hPSC-derived neurons can also be used for disease modeling and drug screening. Since the most urgent problem today in transplantation is the lack of suitable donor organs and tissues, the derivation of neural progenitor cells from hPSCs has opened a new avenue for regenerative medicine. In this review, we summarize the recent reports that show how to generate neural derivatives from hPSCs, and discuss the current evidence of using these cells in animal studies. We also highlight the possibilities and concerns of translating these hPSC-derived neurons for biomedical and clinical uses in order to fight against neurological disorders.
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spelling pubmed-37933242013-10-29 Biomedical and Clinical Promises of Human Pluripotent Stem Cells for Neurological Disorders Jongkamonwiwat, Nopporn Noisa, Parinya Biomed Res Int Review Article Neurological disorders are characterized by the chronic and progressive loss of neuronal structures and functions. There is a variability of the onsets and causes of clinical manifestations. Cell therapy has brought a new concept to overcome brain diseases, but the advancement of this therapy is limited by the demands of specialized neurons. Human pluripotent stem cells (hPSCs) have been promised as a renewable resource for generating human neurons for both laboratory and clinical purposes. By the modulations of appropriate signalling pathways, desired neuron subtypes can be obtained, and induced pluripotent stem cells (iPSCs) provide genetically matched neurons for treating patients. These hPSC-derived neurons can also be used for disease modeling and drug screening. Since the most urgent problem today in transplantation is the lack of suitable donor organs and tissues, the derivation of neural progenitor cells from hPSCs has opened a new avenue for regenerative medicine. In this review, we summarize the recent reports that show how to generate neural derivatives from hPSCs, and discuss the current evidence of using these cells in animal studies. We also highlight the possibilities and concerns of translating these hPSC-derived neurons for biomedical and clinical uses in order to fight against neurological disorders. Hindawi Publishing Corporation 2013 2013-09-22 /pmc/articles/PMC3793324/ /pubmed/24171168 http://dx.doi.org/10.1155/2013/656531 Text en Copyright © 2013 N. Jongkamonwiwat and P. Noisa. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jongkamonwiwat, Nopporn
Noisa, Parinya
Biomedical and Clinical Promises of Human Pluripotent Stem Cells for Neurological Disorders
title Biomedical and Clinical Promises of Human Pluripotent Stem Cells for Neurological Disorders
title_full Biomedical and Clinical Promises of Human Pluripotent Stem Cells for Neurological Disorders
title_fullStr Biomedical and Clinical Promises of Human Pluripotent Stem Cells for Neurological Disorders
title_full_unstemmed Biomedical and Clinical Promises of Human Pluripotent Stem Cells for Neurological Disorders
title_short Biomedical and Clinical Promises of Human Pluripotent Stem Cells for Neurological Disorders
title_sort biomedical and clinical promises of human pluripotent stem cells for neurological disorders
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793324/
https://www.ncbi.nlm.nih.gov/pubmed/24171168
http://dx.doi.org/10.1155/2013/656531
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