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Paraoxonase is reduced in patients with growth hormone deficiency: A novel risk factor for atherosclerosis

BACKGROUND: Growth hormone deficiency (GHD) is associated with an increased cardiovascular mortality. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. In the present study, we aimed to evaluate oxidant and antioxidant status in patients...

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Autores principales: Bayram, Fahri, Baskol, Gulden, Tanriverdi, Fatih, Baskol, Mevlut, Kocer, Derya, Caniklioğlu, Ayşen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793373/
https://www.ncbi.nlm.nih.gov/pubmed/24124425
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author Bayram, Fahri
Baskol, Gulden
Tanriverdi, Fatih
Baskol, Mevlut
Kocer, Derya
Caniklioğlu, Ayşen
author_facet Bayram, Fahri
Baskol, Gulden
Tanriverdi, Fatih
Baskol, Mevlut
Kocer, Derya
Caniklioğlu, Ayşen
author_sort Bayram, Fahri
collection PubMed
description BACKGROUND: Growth hormone deficiency (GHD) is associated with an increased cardiovascular mortality. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. In the present study, we aimed to evaluate oxidant and antioxidant status in patients with GHD by analyzing serum paraoxonase1 (PON1) activity, and malondialdehyde (MDA) and thiol levels. MATERIALS AND METHODS: This study was a case–control study. Thirty patients with GHD were included in the study and compared with 20 healthy controls. Serum PON1 activity, and MDA and thiol levels were measured according to an enzymatic spectrophotometric method. RESULTS: Serum MDA levels (2.8 ± 1.3 nmol/mL) were higher in GHD group than the controls (1.7 ± 0.5 nmol/mL) (P = 0.001). PON1 activity (149.9 ± 77.9 U/L) was lower in GHD group than the controls (286.3 ± 126.7 U/L) (P = 0.001). Thiol and high-density lipoprotein cholesterol (HDL-cholesterol) levels were lower in GHD group (218.6 ± 103.9 µmol/L and 32.6 ± 13.4 mg/dL, respectively) than the controls (289.6 ± 101.1 µmol/L and 54.3 ± 14.9 mg/dL, respectively) (P = 0.021 and P = 0.001, respectively). In GHD patients, serum MDA level was negatively correlated with serum HDL-cholesterol (r = −0.499, P = 0.001), and serum PON1 activity was positively correlated with serum thiol and HDL-cholesterol levels (r = 0.306, P = 0.032 and r = 0.303, P = 0.033, respectively). CONCLUSION: These data support that GHD is characterized by an imbalance between oxidant and antioxidant factors. This abnormality may contribute to the increased atherogenic risk in patients with GHD.
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spelling pubmed-37933732013-10-11 Paraoxonase is reduced in patients with growth hormone deficiency: A novel risk factor for atherosclerosis Bayram, Fahri Baskol, Gulden Tanriverdi, Fatih Baskol, Mevlut Kocer, Derya Caniklioğlu, Ayşen J Res Med Sci Original Article BACKGROUND: Growth hormone deficiency (GHD) is associated with an increased cardiovascular mortality. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. In the present study, we aimed to evaluate oxidant and antioxidant status in patients with GHD by analyzing serum paraoxonase1 (PON1) activity, and malondialdehyde (MDA) and thiol levels. MATERIALS AND METHODS: This study was a case–control study. Thirty patients with GHD were included in the study and compared with 20 healthy controls. Serum PON1 activity, and MDA and thiol levels were measured according to an enzymatic spectrophotometric method. RESULTS: Serum MDA levels (2.8 ± 1.3 nmol/mL) were higher in GHD group than the controls (1.7 ± 0.5 nmol/mL) (P = 0.001). PON1 activity (149.9 ± 77.9 U/L) was lower in GHD group than the controls (286.3 ± 126.7 U/L) (P = 0.001). Thiol and high-density lipoprotein cholesterol (HDL-cholesterol) levels were lower in GHD group (218.6 ± 103.9 µmol/L and 32.6 ± 13.4 mg/dL, respectively) than the controls (289.6 ± 101.1 µmol/L and 54.3 ± 14.9 mg/dL, respectively) (P = 0.021 and P = 0.001, respectively). In GHD patients, serum MDA level was negatively correlated with serum HDL-cholesterol (r = −0.499, P = 0.001), and serum PON1 activity was positively correlated with serum thiol and HDL-cholesterol levels (r = 0.306, P = 0.032 and r = 0.303, P = 0.033, respectively). CONCLUSION: These data support that GHD is characterized by an imbalance between oxidant and antioxidant factors. This abnormality may contribute to the increased atherogenic risk in patients with GHD. Medknow Publications & Media Pvt Ltd 2013-04 /pmc/articles/PMC3793373/ /pubmed/24124425 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bayram, Fahri
Baskol, Gulden
Tanriverdi, Fatih
Baskol, Mevlut
Kocer, Derya
Caniklioğlu, Ayşen
Paraoxonase is reduced in patients with growth hormone deficiency: A novel risk factor for atherosclerosis
title Paraoxonase is reduced in patients with growth hormone deficiency: A novel risk factor for atherosclerosis
title_full Paraoxonase is reduced in patients with growth hormone deficiency: A novel risk factor for atherosclerosis
title_fullStr Paraoxonase is reduced in patients with growth hormone deficiency: A novel risk factor for atherosclerosis
title_full_unstemmed Paraoxonase is reduced in patients with growth hormone deficiency: A novel risk factor for atherosclerosis
title_short Paraoxonase is reduced in patients with growth hormone deficiency: A novel risk factor for atherosclerosis
title_sort paraoxonase is reduced in patients with growth hormone deficiency: a novel risk factor for atherosclerosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793373/
https://www.ncbi.nlm.nih.gov/pubmed/24124425
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