Identification of homogeneously staining regions in leukemia patients

Homogeneously staining regions (HSR) or double minute chromosomes (dmin) are autonomously replicating extra-chromosomal elements that are frequently associated with gene amplification in a variety of cancers. The diagnosis of leukemia patients was based on characterization of the leukemic cells obta...

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Detalles Bibliográficos
Autores principales: Moghadam, Mohammad Heydarian, Movafagh, Abolfazl, Omrani, MirDavood, Ghanati, Kiandokht, Hashemi, Mehrdad, Poursafavi, Farhikhteh, Darvish, Hossein, Abdolahi, Davood Zare, Gholami, Milad, Heidari Rostamy, Mohammad Reza, Safari, Shamsi, HaghNejad, Leyla, Darehgazani, Reyhaneh, Naeini, Niloofar Safavi, Motlagh, Mehdi Ghandehari, Amani, Davar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793386/
https://www.ncbi.nlm.nih.gov/pubmed/24124438
Descripción
Sumario:Homogeneously staining regions (HSR) or double minute chromosomes (dmin) are autonomously replicating extra-chromosomal elements that are frequently associated with gene amplification in a variety of cancers. The diagnosis of leukemia patients was based on characterization of the leukemic cells obtained from bone marrow cytogenetics. This study report two cases, one with Acute Myeloblastic Leukemia without maturation (AML-M1), aged 23-year-old female, and the other with chronic myelogenous leukemia (CML)-blast crisis, a 28-year-old female associated with double minute chromosomes. Most cases of acute myeloid leukemia with dmin in the literature (including our cases) have been diagnosed as having acute myeloid leukemia.

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