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5-Fluoro-N-(2-methyl-3-oxo-1-thia-4-azaspiro[4.5]dec-4-yl)-3-phenyl-1H-indole-2-carboxamide
In the title compound, C(24)H(24)FN(3)O(2)S, the 1,3-thiazolidine ring adopts an envelope conformation with the S atom as the flap, while the cyclohexane ring is in a chair conformation. In the crystal, molecules are linked by N—H⋯O and C—H⋯F hydrogen bonds, forming a three-dimensional network. T...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793733/ https://www.ncbi.nlm.nih.gov/pubmed/24109320 http://dx.doi.org/10.1107/S1600536813018576 |
Sumario: | In the title compound, C(24)H(24)FN(3)O(2)S, the 1,3-thiazolidine ring adopts an envelope conformation with the S atom as the flap, while the cyclohexane ring is in a chair conformation. In the crystal, molecules are linked by N—H⋯O and C—H⋯F hydrogen bonds, forming a three-dimensional network. The unit cell contains six voids of 57 Å(3), but the residual electron density (highest peak = 0.23 e Å(−3) and deepest hole = −0.19 e Å(−3)) in the difference Fourier map suggests no solvent molecule occupies this void. |
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