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5′′-(2-Fluorobenzylidene)-1′-(2-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a’-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione
In the title compound, C(37)H(32)F(2)N(2)O(2), the central six-membered piperidine ring adopts a twisted half-chair conformation, with the N and methylene C atoms deviating by −0.2875 (16) and 0.4965 (15) Å, respectively, from the mean plane defined by the other four atoms. The piperidine connected...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793784/ https://www.ncbi.nlm.nih.gov/pubmed/24109371 http://dx.doi.org/10.1107/S1600536813019594 |
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author | Vishnupriya, R. Suresh, J. Sivakumar, S. Kumar, R. Ranjith Lakshman, P. L. Nilantha |
author_facet | Vishnupriya, R. Suresh, J. Sivakumar, S. Kumar, R. Ranjith Lakshman, P. L. Nilantha |
author_sort | Vishnupriya, R. |
collection | PubMed |
description | In the title compound, C(37)H(32)F(2)N(2)O(2), the central six-membered piperidine ring adopts a twisted half-chair conformation, with the N and methylene C atoms deviating by −0.2875 (16) and 0.4965 (15) Å, respectively, from the mean plane defined by the other four atoms. The piperidine connected to the octahydroindolizine ring is in a half-chair conformation. The five-membered pyrrole ring adopts a slightly twisted envelope conformation with the piperidine C atom as the flap atom. The F and H atoms of both fluorobenzene rings are disordered, with occupancy factors of 0.941 (3):0.059 (3) and 0.863 (3):0.137 (3). The molecular structure features some intramolecular C—H⋯O interactions. In the crystal, a supramolecular zigzag chain sustained by C—H⋯F interactions parallel to the c axis is formed, generating a C(12) graph-set motif. |
format | Online Article Text |
id | pubmed-3793784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-37937842013-10-09 5′′-(2-Fluorobenzylidene)-1′-(2-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a’-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione Vishnupriya, R. Suresh, J. Sivakumar, S. Kumar, R. Ranjith Lakshman, P. L. Nilantha Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(37)H(32)F(2)N(2)O(2), the central six-membered piperidine ring adopts a twisted half-chair conformation, with the N and methylene C atoms deviating by −0.2875 (16) and 0.4965 (15) Å, respectively, from the mean plane defined by the other four atoms. The piperidine connected to the octahydroindolizine ring is in a half-chair conformation. The five-membered pyrrole ring adopts a slightly twisted envelope conformation with the piperidine C atom as the flap atom. The F and H atoms of both fluorobenzene rings are disordered, with occupancy factors of 0.941 (3):0.059 (3) and 0.863 (3):0.137 (3). The molecular structure features some intramolecular C—H⋯O interactions. In the crystal, a supramolecular zigzag chain sustained by C—H⋯F interactions parallel to the c axis is formed, generating a C(12) graph-set motif. International Union of Crystallography 2013-07-20 /pmc/articles/PMC3793784/ /pubmed/24109371 http://dx.doi.org/10.1107/S1600536813019594 Text en © Vishnupriya et al. 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Vishnupriya, R. Suresh, J. Sivakumar, S. Kumar, R. Ranjith Lakshman, P. L. Nilantha 5′′-(2-Fluorobenzylidene)-1′-(2-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a’-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione |
title | 5′′-(2-Fluorobenzylidene)-1′-(2-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a’-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione |
title_full | 5′′-(2-Fluorobenzylidene)-1′-(2-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a’-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione |
title_fullStr | 5′′-(2-Fluorobenzylidene)-1′-(2-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a’-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione |
title_full_unstemmed | 5′′-(2-Fluorobenzylidene)-1′-(2-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a’-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione |
title_short | 5′′-(2-Fluorobenzylidene)-1′-(2-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a’-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione |
title_sort | 5′′-(2-fluorobenzylidene)-1′-(2-fluorophenyl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a’-octahydrodispiro[acenaphthylene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1h)-dione |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793784/ https://www.ncbi.nlm.nih.gov/pubmed/24109371 http://dx.doi.org/10.1107/S1600536813019594 |
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