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N-tert-Butoxycarbonyl-α-(2-fluorobenzyl)-l-proline
In the title compound, C(17)H(22)FNO(4), the pyrrolidine ring adopts an envelope conformation with the disordered components of the methylene C atom, with site occupancies of 0.896 (7) and 0.104 (7), being the flap on either side of the mean plane involving the other atoms of the ring. The carboxy...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793788/ https://www.ncbi.nlm.nih.gov/pubmed/24109375 http://dx.doi.org/10.1107/S1600536813019788 |
Sumario: | In the title compound, C(17)H(22)FNO(4), the pyrrolidine ring adopts an envelope conformation with the disordered components of the methylene C atom, with site occupancies of 0.896 (7) and 0.104 (7), being the flap on either side of the mean plane involving the other atoms of the ring. The carboxylic acid group forms dihedral angles of 72.06 (11) and 45.44 (5)° with the N-tert-butoxycarbonyl group and the 2-fluorobenzyl group, respectively. In the crystal, two-dimensional layers of molecules parallel to (001) are built through an R (4) (4)(23) motif generated via O—H⋯O, C—H⋯O and C—H⋯F interactions, and an R (2) (2)(11) motif generated by C—H⋯O and C—H⋯F interactions. |
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