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N-tert-But­oxy­carbonyl-α-(2-fluoro­benzyl)-l-proline

In the title compound, C(17)H(22)FNO(4), the pyrrolidine ring adopts an envelope conformation with the disordered com­ponents of the methylene C atom, with site occupancies of 0.896 (7) and 0.104 (7), being the flap on either side of the mean plane involving the other atoms of the ring. The carb­oxy...

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Detalles Bibliográficos
Autores principales: Rajalakshmi, P., Srinivasan, N., Krishnakumar, R. V., Razak, Ibrahim Abdul, Rosli, Mohd Mustaqim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793788/
https://www.ncbi.nlm.nih.gov/pubmed/24109375
http://dx.doi.org/10.1107/S1600536813019788
Descripción
Sumario:In the title compound, C(17)H(22)FNO(4), the pyrrolidine ring adopts an envelope conformation with the disordered com­ponents of the methylene C atom, with site occupancies of 0.896 (7) and 0.104 (7), being the flap on either side of the mean plane involving the other atoms of the ring. The carb­oxy­lic acid group forms dihedral angles of 72.06 (11) and 45.44 (5)° with the N-tert-but­oxy­carbonyl group and the 2-fluoro­benzyl group, respectively. In the crystal, two-dimensional layers of mol­ecules parallel to (001) are built through an R (4) (4)(23) motif generated via O—H⋯O, C—H⋯O and C—H⋯F inter­actions, and an R (2) (2)(11) motif generated by C—H⋯O and C—H⋯F inter­actions.