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1-Ethyl-4′-(1H-indol-3-ylcarbonyl)-1′-methyl-2,2′′-dioxodispiro[indoline-3,2′-pyrrolidine-3′,3′′-indoline]-4′-carbonitrile dimethyl sulfoxide monosolvate
In the title compound, C(31)H(25)N(5)O(3)·C(2)H(6)OS, the three indole/indoline units are all essentially planar with maximum deviations of 0.0172 (3), 0.053 (2) and 0.07 (2) Å. The pyrrolidine ring adopts an envelope conformation with the C atoms bearing the 1-ethyl-2-oxoindole substituent (in whi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793813/ https://www.ncbi.nlm.nih.gov/pubmed/24109400 http://dx.doi.org/10.1107/S1600536813020485 |
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author | Inglebert, S. Antony Arun, Yuvaraj Sethusankar, K. Perumal, Paramasivam T. |
author_facet | Inglebert, S. Antony Arun, Yuvaraj Sethusankar, K. Perumal, Paramasivam T. |
author_sort | Inglebert, S. Antony |
collection | PubMed |
description | In the title compound, C(31)H(25)N(5)O(3)·C(2)H(6)OS, the three indole/indoline units are all essentially planar with maximum deviations of 0.0172 (3), 0.053 (2) and 0.07 (2) Å. The pyrrolidine ring adopts an envelope conformation with the C atoms bearing the 1-ethyl-2-oxoindole substituent (in which the five-membered ring adopts a twisted conformation) as the flap. The dimethyl sulfoxide solvent molecule is disordered over two positions, with an occupancy factor ratio of 0.871 (4):0.129 (4). The solvent components are linked to the heterocyclic molecule via C—H⋯O and C—H⋯S hydrogen bonds. In the crystal, the solvent components are linked to the heterocyclic molecule via C—H⋯O and C—H⋯S interactions, forming R (2) (2)(10) ring motifs. The molecules are further connected into a chain along the a-axis direction via N—H⋯O hydrogen bonds. |
format | Online Article Text |
id | pubmed-3793813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-37938132013-10-09 1-Ethyl-4′-(1H-indol-3-ylcarbonyl)-1′-methyl-2,2′′-dioxodispiro[indoline-3,2′-pyrrolidine-3′,3′′-indoline]-4′-carbonitrile dimethyl sulfoxide monosolvate Inglebert, S. Antony Arun, Yuvaraj Sethusankar, K. Perumal, Paramasivam T. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(31)H(25)N(5)O(3)·C(2)H(6)OS, the three indole/indoline units are all essentially planar with maximum deviations of 0.0172 (3), 0.053 (2) and 0.07 (2) Å. The pyrrolidine ring adopts an envelope conformation with the C atoms bearing the 1-ethyl-2-oxoindole substituent (in which the five-membered ring adopts a twisted conformation) as the flap. The dimethyl sulfoxide solvent molecule is disordered over two positions, with an occupancy factor ratio of 0.871 (4):0.129 (4). The solvent components are linked to the heterocyclic molecule via C—H⋯O and C—H⋯S hydrogen bonds. In the crystal, the solvent components are linked to the heterocyclic molecule via C—H⋯O and C—H⋯S interactions, forming R (2) (2)(10) ring motifs. The molecules are further connected into a chain along the a-axis direction via N—H⋯O hydrogen bonds. International Union of Crystallography 2013-07-27 /pmc/articles/PMC3793813/ /pubmed/24109400 http://dx.doi.org/10.1107/S1600536813020485 Text en © Inglebert et al. 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Inglebert, S. Antony Arun, Yuvaraj Sethusankar, K. Perumal, Paramasivam T. 1-Ethyl-4′-(1H-indol-3-ylcarbonyl)-1′-methyl-2,2′′-dioxodispiro[indoline-3,2′-pyrrolidine-3′,3′′-indoline]-4′-carbonitrile dimethyl sulfoxide monosolvate |
title | 1-Ethyl-4′-(1H-indol-3-ylcarbonyl)-1′-methyl-2,2′′-dioxodispiro[indoline-3,2′-pyrrolidine-3′,3′′-indoline]-4′-carbonitrile dimethyl sulfoxide monosolvate |
title_full | 1-Ethyl-4′-(1H-indol-3-ylcarbonyl)-1′-methyl-2,2′′-dioxodispiro[indoline-3,2′-pyrrolidine-3′,3′′-indoline]-4′-carbonitrile dimethyl sulfoxide monosolvate |
title_fullStr | 1-Ethyl-4′-(1H-indol-3-ylcarbonyl)-1′-methyl-2,2′′-dioxodispiro[indoline-3,2′-pyrrolidine-3′,3′′-indoline]-4′-carbonitrile dimethyl sulfoxide monosolvate |
title_full_unstemmed | 1-Ethyl-4′-(1H-indol-3-ylcarbonyl)-1′-methyl-2,2′′-dioxodispiro[indoline-3,2′-pyrrolidine-3′,3′′-indoline]-4′-carbonitrile dimethyl sulfoxide monosolvate |
title_short | 1-Ethyl-4′-(1H-indol-3-ylcarbonyl)-1′-methyl-2,2′′-dioxodispiro[indoline-3,2′-pyrrolidine-3′,3′′-indoline]-4′-carbonitrile dimethyl sulfoxide monosolvate |
title_sort | 1-ethyl-4′-(1h-indol-3-ylcarbonyl)-1′-methyl-2,2′′-dioxodispiro[indoline-3,2′-pyrrolidine-3′,3′′-indoline]-4′-carbonitrile dimethyl sulfoxide monosolvate |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793813/ https://www.ncbi.nlm.nih.gov/pubmed/24109400 http://dx.doi.org/10.1107/S1600536813020485 |
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