Cargando…

IGF-IR Promotes Prostate Cancer Growth by Stabilizing α(5)β(1) Integrin Protein Levels

Dynamic crosstalk between growth factor receptors, cell adhesion molecules and extracellular matrix is essential for cancer cell migration and invasion. Integrins are transmembrane receptors that bind extracellular matrix proteins and enable cell adhesion and cytoskeletal organization. They also med...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sayeed, Aejaz, Fedele, Carmine, Trerotola, Marco, Ganguly, Kirat K., Languino, Lucia R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793919/ https://www.ncbi.nlm.nih.gov/pubmed/24130778 http://dx.doi.org/10.1371/journal.pone.0076513

Ejemplares similares

Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts
por: Trerotola, Marco, et al.
Publicado: (2015)

Erratum: Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts
por: Trerotola, Marco, et al.
Publicado: (2015)

β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation
por: Sayeed, Aejaz, et al.
Publicado: (2016)

Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth
por: DeRita, Rachel M., et al.
Publicado: (2019)

Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression
por: Quaglia, Fabio, et al.
Publicado: (2021)

α(v)β(3) integrin expression up-regulates cdc2, which modulates cell migration
por: Manes, Thomas, et al.
Publicado: (2003)

Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by β(1) integrins
por: Goel, Hira Lal, et al.
Publicado: (2004)

Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells
por: Krishn, Shiv Ram, et al.
Publicado: (2022)

IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
por: Li, Heming, et al.
Publicado: (2017)

The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis
por: Krishn, Shiv Ram, et al.
Publicado: (2020)

Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis
por: Beneit, N., et al.
Publicado: (2016)

Small extracellular vesicles modulated by αVβ3 integrin induce neuroendocrine differentiation in recipient cancer cells
por: Quaglia, Fabio, et al.
Publicado: (2020)

The NOGO receptor NgR2, a novel αVβ3 integrin effector, induces neuroendocrine differentiation in prostate cancer
por: Quaglia, Fabio, et al.
Publicado: (2022)

Novel cross-talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses
por: Malaguarnera, Roberta, et al.
Publicado: (2015)

Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension
por: Cormier, Anthony, et al.
Publicado: (2018)

Interaction between IGF-IR and ER Induced by E2 and IGF-I
por: Yu, Zhenghong, et al.
Publicado: (2013)

VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling
por: Gao, Xiu Kui, et al.
Publicado: (2023)

IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR
por: Rojas, Andres, et al.
Publicado: (2011)

IGF-IR Internalizes with Caveolin-1 and PTRF/Cavin in Hacat Cells
por: Salani, Barbara, et al.
Publicado: (2010)

Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR–IGF1R hybrid receptor modulators
por: Turvey, Samuel J., et al.
Publicado: (2022)

The Role of IGF/IGF-IR-Signaling and Extracellular Matrix Effectors in Bone Sarcoma Pathogenesis
por: Tzanakakis, George N., et al.
Publicado: (2021)

Immunolocalization of insulin-like growth factor-I (IGF-I) and its receptors (IGF-IR) in the equine epididymis
por: YOON, Minjung, et al.
Publicado: (2014)

IGF-IR determines the fates of BCR/ABL leukemia
por: Xie, Jingjing, et al.
Publicado: (2015)

IGF-IR Targeted Therapy: Past, Present and Future
por: Janssen, Joseph A. M. J. L., et al.
Publicado: (2014)

Crk II silencing down-regulates IGF-IR and inhibits migration and invasion of prostate cancer cells
por: Dhupkar, Pooja, et al.
Publicado: (2016)

Comprehensive analysis of integrin αvβ3/α6β1 in prognosis and immune escape of prostate cancer
por: Liu, Yang, et al.
Publicado: (2023)

Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells
por: Arous, Caroline, et al.
Publicado: (2021)

The IGF-Independent Role of IRS-2 in the Secretion of MMP-9 Enhances the Growth of Prostate Carcinoma Cell Line PC3
por: Furuta, Haruka, et al.
Publicado: (2023)

IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
por: Yoneyama, Yosuke, et al.
Publicado: (2018)

Aptamer-mediated impairment of EGFR-integrin αvβ3 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers
por: Camorani, Simona, et al.
Publicado: (2017)

Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion
por: Rullo, Jacob, et al.
Publicado: (2012)

Regulation of Kinase Signaling Pathways by α6β4-Integrins and Plectin in Prostate Cancer
por: Koivusalo, Saara, et al.
Publicado: (2022)

Methods for extracellular vesicle isolation from cancer cells
por: Salem, Israa, et al.
Publicado: (2020)

The novel IGF-IR/Akt–dependent anticancer activities of glucosamine
por: Song, Ki-Hoon, et al.
Publicado: (2014)

Cross-Talk between Adiponectin and IGF-IR in Breast Cancer
por: Mauro, Loredana, et al.
Publicado: (2015)

IGF-IR: a new prognostic biomarker for human glioblastoma
por: Maris, C, et al.
Publicado: (2015)

Calreticulin Regulates β1-Integrin mRNA Stability in PC-3 Prostate Cancer Cells
por: Lin, Yueh-Chien, et al.
Publicado: (2022)

Optimized serum stability and specificity of an αvβ6 integrin-binding peptide for tumor targeting
por: Cardle, Ian I., et al.
Publicado: (2021)

Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells
por: Avino, Silvia, et al.
Publicado: (2016)

Integrin α2β1 decelerates proliferation, but promotes survival and invasion of prostate cancer cells
por: Ojalill, Marjaana, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_s1801a2d6mtdh9jrgfpjm0l75p