Large Extent of Disorder in Adenomatous Polyposis Coli Offers a Strategy to Guard Wnt Signalling against Point Mutations

Mutations in the central region of the signalling hub Adenomatous Polyposis Coli (APC) cause colorectal tumourigenesis. The structure of this region remained unknown. Here, we characterise the Mutation Cluster Region in APC (APC-MCR) as intrinsically disordered and propose a model how this structura...

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Detalles Bibliográficos
Autores principales: Minde, David P., Radli, Martina, Forneris, Federico, Maurice, Madelon M., Rüdiger, Stefan G. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793970/
https://www.ncbi.nlm.nih.gov/pubmed/24130866
http://dx.doi.org/10.1371/journal.pone.0077257

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