Retromer Dependent Recycling of the Wnt Secretion Factor Wls Is Dispensable for Stem Cell Maintenance in the Mammalian Intestinal Epithelium

In C. elegans and Drosophila, retromer mediated retrograde transport of Wntless (Wls) from endosomes to the trans-Golgi network (TGN) is required for Wnt secretion. When this retrograde transport pathway is blocked, Wls is missorted to lysosomes and degraded, resulting in reduced Wnt secretion and v...

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Detalles Bibliográficos
Autores principales: de Groot, Reinoud E. A., Farin, Henner F., Macůrková, Marie, van Es, Johan H., Clevers, Hans C., Korswagen, Hendrik C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793972/
https://www.ncbi.nlm.nih.gov/pubmed/24130821
http://dx.doi.org/10.1371/journal.pone.0076971

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