The Housekeeping Gene Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) Regulates Multiple Developmental and Metabolic Pathways of Murine Embryonic Stem Cell Neuronal Differentiation

The mechanisms by which mutations of the purinergic housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) cause the severe neurodevelopmental Lesch Nyhan Disease (LND) are poorly understood. The best recognized neural consequences of HPRT deficiency are defective basal ganglia expr...

Descripción completa

Detalles Bibliográficos
Autores principales: Kang, Tae Hyuk, Park, Yongjin, Bader, Joel S., Friedmann, Theodore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794013/
https://www.ncbi.nlm.nih.gov/pubmed/24130677
http://dx.doi.org/10.1371/journal.pone.0074967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794013/
https://www.ncbi.nlm.nih.gov/pubmed/24130677
http://dx.doi.org/10.1371/journal.pone.0074967

Ejemplares similares