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Crystal Structure of a Bioactive Pactamycin Analog Bound to the 30S Ribosomal Subunit()

Biosynthetically and chemically derived analogs of the antibiotic pactamycin and de-6-methylsalicylyl (MSA)-pactamycin have attracted recent interest as potential antiprotozoal and antitumor drugs. Here, we report a 3.1-Å crystal structure of de-6-MSA-pactamycin bound to its target site on the Therm...

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Detalles Bibliográficos
Autores principales:	Tourigny, David S., Fernández, Israel S., Kelley, Ann C., Vakiti, Ramkrishna Reddy, Chattopadhyay, Amit Kumar, Dorich, Stéphane, Hanessian, Stephen, Ramakrishnan, V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2013
Materias:	Brevia
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794158/ https://www.ncbi.nlm.nih.gov/pubmed/23702293 http://dx.doi.org/10.1016/j.jmb.2013.05.004

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