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Amino acid composition of proteins reduces deleterious impact of mutations
The evolutionary origin of amino acid occurrence frequencies in proteins (composition) is not yet fully understood. We suggest that protein composition works alongside the genetic code to minimize impact of mutations on protein structure. First, we propose a novel method for estimating thermodynamic...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794375/ https://www.ncbi.nlm.nih.gov/pubmed/24108121 http://dx.doi.org/10.1038/srep02919 |