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Bone Response to Surface-Modified Titanium Implants: Studies on the Early Tissue Response to Implants with Different Surface Characteristics

In a series of experimental studies, the bone formation around systematically modified titanium implants is analyzed. In the present study, three different surface modifications were prepared and evaluated. Glow-discharge cleaning and oxidizing resulted in a highly stoichiometric TiO(2) surface, whi...

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Autores principales: Larsson Wexell, C., Thomsen, P., Aronsson, B.-O., Tengvall, P., Rodahl, M., Lausmaa, J., Kasemo, B., Ericson, L. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794548/
https://www.ncbi.nlm.nih.gov/pubmed/24174936
http://dx.doi.org/10.1155/2013/412482
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author Larsson Wexell, C.
Thomsen, P.
Aronsson, B.-O.
Tengvall, P.
Rodahl, M.
Lausmaa, J.
Kasemo, B.
Ericson, L. E.
author_facet Larsson Wexell, C.
Thomsen, P.
Aronsson, B.-O.
Tengvall, P.
Rodahl, M.
Lausmaa, J.
Kasemo, B.
Ericson, L. E.
author_sort Larsson Wexell, C.
collection PubMed
description In a series of experimental studies, the bone formation around systematically modified titanium implants is analyzed. In the present study, three different surface modifications were prepared and evaluated. Glow-discharge cleaning and oxidizing resulted in a highly stoichiometric TiO(2) surface, while a glow-discharge treatment in nitrogen gas resulted in implants with essentially a surface of titanium nitride, covered with a very thin titanium oxide. Finally, hydrogen peroxide treatment of implants resulted in an almost stoichiometric TiO(2), rich in hydroxyl groups on the surface. Machined commercially pure titanium implants served as controls. Scanning Auger Electron Spectroscopy, Scanning Electron Microscopy, and Atomic Force Microscopy revealed no significant differences in oxide thickness or surface roughness parameters, but differences in the surface chemical composition and apparent topography were observed. After surface preparation, the implants were inserted in cortical bone of rabbits and evaluated after 1, 3, and 6 weeks. Light microscopic evaluation of the tissue response showed that all implants were in contact with bone and had a large proportion of newly formed bone within the threads after 6 weeks. There were no morphological differences between the four groups. Our study shows that a high degree of bone contact and bone formation can be achieved with titanium implants of different surface composition and topography.
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spelling pubmed-37945482013-10-30 Bone Response to Surface-Modified Titanium Implants: Studies on the Early Tissue Response to Implants with Different Surface Characteristics Larsson Wexell, C. Thomsen, P. Aronsson, B.-O. Tengvall, P. Rodahl, M. Lausmaa, J. Kasemo, B. Ericson, L. E. Int J Biomater Research Article In a series of experimental studies, the bone formation around systematically modified titanium implants is analyzed. In the present study, three different surface modifications were prepared and evaluated. Glow-discharge cleaning and oxidizing resulted in a highly stoichiometric TiO(2) surface, while a glow-discharge treatment in nitrogen gas resulted in implants with essentially a surface of titanium nitride, covered with a very thin titanium oxide. Finally, hydrogen peroxide treatment of implants resulted in an almost stoichiometric TiO(2), rich in hydroxyl groups on the surface. Machined commercially pure titanium implants served as controls. Scanning Auger Electron Spectroscopy, Scanning Electron Microscopy, and Atomic Force Microscopy revealed no significant differences in oxide thickness or surface roughness parameters, but differences in the surface chemical composition and apparent topography were observed. After surface preparation, the implants were inserted in cortical bone of rabbits and evaluated after 1, 3, and 6 weeks. Light microscopic evaluation of the tissue response showed that all implants were in contact with bone and had a large proportion of newly formed bone within the threads after 6 weeks. There were no morphological differences between the four groups. Our study shows that a high degree of bone contact and bone formation can be achieved with titanium implants of different surface composition and topography. Hindawi Publishing Corporation 2013 2013-09-23 /pmc/articles/PMC3794548/ /pubmed/24174936 http://dx.doi.org/10.1155/2013/412482 Text en Copyright © 2013 C. Larsson Wexell et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Larsson Wexell, C.
Thomsen, P.
Aronsson, B.-O.
Tengvall, P.
Rodahl, M.
Lausmaa, J.
Kasemo, B.
Ericson, L. E.
Bone Response to Surface-Modified Titanium Implants: Studies on the Early Tissue Response to Implants with Different Surface Characteristics
title Bone Response to Surface-Modified Titanium Implants: Studies on the Early Tissue Response to Implants with Different Surface Characteristics
title_full Bone Response to Surface-Modified Titanium Implants: Studies on the Early Tissue Response to Implants with Different Surface Characteristics
title_fullStr Bone Response to Surface-Modified Titanium Implants: Studies on the Early Tissue Response to Implants with Different Surface Characteristics
title_full_unstemmed Bone Response to Surface-Modified Titanium Implants: Studies on the Early Tissue Response to Implants with Different Surface Characteristics
title_short Bone Response to Surface-Modified Titanium Implants: Studies on the Early Tissue Response to Implants with Different Surface Characteristics
title_sort bone response to surface-modified titanium implants: studies on the early tissue response to implants with different surface characteristics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794548/
https://www.ncbi.nlm.nih.gov/pubmed/24174936
http://dx.doi.org/10.1155/2013/412482
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